Coronary collateral development in the rhesus monkey (Macaca mulatta)

D. D. Buss, D. M. Hyde, Eugene Steffey

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clinical signs referable to myocardial ischemia. The hearts were excised at 12 weeks postsurgery for perfusion fixation and coronary vascular injection with barium-gelatin. All hearts exhibited infarction scars in the circumflex-perfused regions, with infarcts varying from a transmural scar to cases with a thin margin of surviving myocardium at the epicardial surface. Coronary collaterals were infrequent and small in size, and particularly evident in the atria. We conclude that the rhesus monkey is unable to develop sufficient coronary collateral blood flow to prevent myocardial infarction after gradual, total coronary occlusion with ameroid constrictors.

Original languageEnglish (US)
Pages (from-to)510-517
Number of pages8
JournalBasic Research in Cardiology
Volume78
Issue number5
DOIs
StatePublished - Sep 1983

Fingerprint

Macaca mulatta
Cicatrix
Myocardial Infarction
Coronary Occlusion
Barium
Gelatin
Ambulatory Surgical Procedures
Infarction
Myocardial Ischemia
Blood Vessels
Coronary Vessels
Myocardium
Perfusion
Injections
ameroid

Keywords

  • cardiac pathology
  • coronary circulation
  • coronary collaterals
  • myocardial infarction
  • non-human primates

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary collateral development in the rhesus monkey (Macaca mulatta). / Buss, D. D.; Hyde, D. M.; Steffey, Eugene.

In: Basic Research in Cardiology, Vol. 78, No. 5, 09.1983, p. 510-517.

Research output: Contribution to journalArticle

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