Abstract
Purpose: To compare the diagnostic power of different software implementations for the quantification of coronary artery calcium. Materials and Methods: Electron beam computed tomography was performed in 109 heart transplant recipients at the same time as catheter coronary angiography and intracoronary ultrasound. Electron beam computed tomography images were analyzed by 3 software packages marketed for the quantification of coronary calcifications using the same software settings, and the resultant calcium scores correlated with the invasive reference methods by Bland-Altman plots and analysis of the receiver operating characteristics. Results: Although all scoring systems displayed close correlations upon regression analysis (r 2 = 0.94-0.99), their ability to detect disease as per the invasive reference method varied significantly in some instances. The area under the ROC curve varied between Az = 0.78 and 0.85 for the detection of coronary artery stenosis upon coronary angiography (P = 0.05-0.13), and between Az = 0.75 and 0.83 for the detection of accelerated intimal proliferation (P = 0.03-0.18). Conclusions: Different software implementations for the quantification of coronary artery calcium load may display diagnostically relevant differences in spite of close direct correlation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 761-768 |
| Number of pages | 8 |
| Journal | Investigative Radiology |
| Volume | 38 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2003 |
| Externally published | Yes |
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Keywords
- Comparative studies
- Computed tomography (CT)
- Coronary vessels and CT
- Coronary vessels calcification
- Electron beam computed tomography (EBCT)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Coronary Artery Calcium Scoring : Diagnostic Accuracy of Different Software Implementations. / Knollmann, Friedrich D; Helmig, Klaus; Kapell, Susanne; Hummel, Manfred; Bocksch, Wolfgang; Hetzer, Roland; Felix, Roland.
In: Investigative Radiology, Vol. 38, No. 12, 12.2003, p. 761-768.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coronary Artery Calcium Scoring
T2 - Diagnostic Accuracy of Different Software Implementations
AU - Knollmann, Friedrich D
AU - Helmig, Klaus
AU - Kapell, Susanne
AU - Hummel, Manfred
AU - Bocksch, Wolfgang
AU - Hetzer, Roland
AU - Felix, Roland
PY - 2003/12
Y1 - 2003/12
N2 - Purpose: To compare the diagnostic power of different software implementations for the quantification of coronary artery calcium. Materials and Methods: Electron beam computed tomography was performed in 109 heart transplant recipients at the same time as catheter coronary angiography and intracoronary ultrasound. Electron beam computed tomography images were analyzed by 3 software packages marketed for the quantification of coronary calcifications using the same software settings, and the resultant calcium scores correlated with the invasive reference methods by Bland-Altman plots and analysis of the receiver operating characteristics. Results: Although all scoring systems displayed close correlations upon regression analysis (r 2 = 0.94-0.99), their ability to detect disease as per the invasive reference method varied significantly in some instances. The area under the ROC curve varied between Az = 0.78 and 0.85 for the detection of coronary artery stenosis upon coronary angiography (P = 0.05-0.13), and between Az = 0.75 and 0.83 for the detection of accelerated intimal proliferation (P = 0.03-0.18). Conclusions: Different software implementations for the quantification of coronary artery calcium load may display diagnostically relevant differences in spite of close direct correlation.
AB - Purpose: To compare the diagnostic power of different software implementations for the quantification of coronary artery calcium. Materials and Methods: Electron beam computed tomography was performed in 109 heart transplant recipients at the same time as catheter coronary angiography and intracoronary ultrasound. Electron beam computed tomography images were analyzed by 3 software packages marketed for the quantification of coronary calcifications using the same software settings, and the resultant calcium scores correlated with the invasive reference methods by Bland-Altman plots and analysis of the receiver operating characteristics. Results: Although all scoring systems displayed close correlations upon regression analysis (r 2 = 0.94-0.99), their ability to detect disease as per the invasive reference method varied significantly in some instances. The area under the ROC curve varied between Az = 0.78 and 0.85 for the detection of coronary artery stenosis upon coronary angiography (P = 0.05-0.13), and between Az = 0.75 and 0.83 for the detection of accelerated intimal proliferation (P = 0.03-0.18). Conclusions: Different software implementations for the quantification of coronary artery calcium load may display diagnostically relevant differences in spite of close direct correlation.
KW - Comparative studies
KW - Computed tomography (CT)
KW - Coronary vessels and CT
KW - Coronary vessels calcification
KW - Electron beam computed tomography (EBCT)
UR - http://www.scopus.com/inward/record.url?scp=0344413800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344413800&partnerID=8YFLogxK
U2 - 10.1097/01.rli.0000084257.43062.c2
DO - 10.1097/01.rli.0000084257.43062.c2
M3 - Article
C2 - 14627893
AN - SCOPUS:0344413800
VL - 38
SP - 761
EP - 768
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 12
ER -