Corneal thickness as a predictor of corneal transplant outcome

David D. Verdier, Alan Sugar, Keith Baratz, Roy Beck, Mariya Dontchev, Steven Dunn, Robin L. Gal, Edward J. Holland, Craig Kollman, Jonathan H. Lass, Mark J Mannis, Jeffrey Penta

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To assess corneal thickness (CT) and correlation with graft outcome after penetrating keratoplasty in the Cornea Donor Study. Methods: A total of 887 subjects with a corneal transplant for a moderate-risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) had postoperative CT measurements throughout a 5-year follow-up time. Relationships between baseline (recipient, donor, and operative) factors and CT were explored. Proportional hazards models were used to assess the association between CT and graft failure. Relationship between CT and cell density was assessed with a longitudinal repeated measures model and Spearman correlation estimates. Results: Higher longitudinal CT measurements were associated with the following: diagnosis of pseudophakic or aphakic corneal edema (P < 0.001), intraocular pressure >25 mm Hg during the first postoperative month (P = 0.003), white (non-Hispanic) donor race (P = 0.002), and respiratory causes of donor death (P < 0.001). Among those without graft failure within the first postoperative year, the 5-year cumulative incidence (±95% confidence interval) of graft failure was 5% ± 5% in those with a 1-year CT ≤500 μm, 5% ± 3% for CT 501 to 550 μm, 7% ± 4% for CT 551 to 600 μm, and 20% ± 11% for CT >600 μm. In a multivariate analysis, both 1-year CT and cell density were associated with subsequent graft failure (P = 0.002 and 0.009). CT increase was modestly associated with endothelial cell loss during follow-up (r = -0.29). Conclusions: During the first 5 years after penetrating keratoplasty, CT can serve as a predictor of graft survival. However, CT is not a substitute for cell density measurement because both measures were independently predictive of graft failure.

Original languageEnglish (US)
Pages (from-to)729-736
Number of pages8
JournalCornea
Volume32
Issue number6
DOIs
StatePublished - Jun 2013

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Transplants
Corneal Pachymetry
Tissue Donors
Corneal Edema
Penetrating Keratoplasty
Cell Count
Fuchs' Endothelial Dystrophy
Graft Survival
Proportional Hazards Models
Cornea
Cause of Death
Multivariate Analysis
Endothelial Cells

Keywords

  • Cornea thickness
  • Cornea transplantation
  • Graft survival

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Verdier, D. D., Sugar, A., Baratz, K., Beck, R., Dontchev, M., Dunn, S., ... Penta, J. (2013). Corneal thickness as a predictor of corneal transplant outcome. Cornea, 32(6), 729-736. https://doi.org/10.1097/ICO.0b013e31827b14c7

Corneal thickness as a predictor of corneal transplant outcome. / Verdier, David D.; Sugar, Alan; Baratz, Keith; Beck, Roy; Dontchev, Mariya; Dunn, Steven; Gal, Robin L.; Holland, Edward J.; Kollman, Craig; Lass, Jonathan H.; Mannis, Mark J; Penta, Jeffrey.

In: Cornea, Vol. 32, No. 6, 06.2013, p. 729-736.

Research output: Contribution to journalArticle

Verdier, DD, Sugar, A, Baratz, K, Beck, R, Dontchev, M, Dunn, S, Gal, RL, Holland, EJ, Kollman, C, Lass, JH, Mannis, MJ & Penta, J 2013, 'Corneal thickness as a predictor of corneal transplant outcome', Cornea, vol. 32, no. 6, pp. 729-736. https://doi.org/10.1097/ICO.0b013e31827b14c7
Verdier DD, Sugar A, Baratz K, Beck R, Dontchev M, Dunn S et al. Corneal thickness as a predictor of corneal transplant outcome. Cornea. 2013 Jun;32(6):729-736. https://doi.org/10.1097/ICO.0b013e31827b14c7
Verdier, David D. ; Sugar, Alan ; Baratz, Keith ; Beck, Roy ; Dontchev, Mariya ; Dunn, Steven ; Gal, Robin L. ; Holland, Edward J. ; Kollman, Craig ; Lass, Jonathan H. ; Mannis, Mark J ; Penta, Jeffrey. / Corneal thickness as a predictor of corneal transplant outcome. In: Cornea. 2013 ; Vol. 32, No. 6. pp. 729-736.
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AU - Verdier, David D.

AU - Sugar, Alan

AU - Baratz, Keith

AU - Beck, Roy

AU - Dontchev, Mariya

AU - Dunn, Steven

AU - Gal, Robin L.

AU - Holland, Edward J.

AU - Kollman, Craig

AU - Lass, Jonathan H.

AU - Mannis, Mark J

AU - Penta, Jeffrey

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N2 - Purpose: To assess corneal thickness (CT) and correlation with graft outcome after penetrating keratoplasty in the Cornea Donor Study. Methods: A total of 887 subjects with a corneal transplant for a moderate-risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) had postoperative CT measurements throughout a 5-year follow-up time. Relationships between baseline (recipient, donor, and operative) factors and CT were explored. Proportional hazards models were used to assess the association between CT and graft failure. Relationship between CT and cell density was assessed with a longitudinal repeated measures model and Spearman correlation estimates. Results: Higher longitudinal CT measurements were associated with the following: diagnosis of pseudophakic or aphakic corneal edema (P < 0.001), intraocular pressure >25 mm Hg during the first postoperative month (P = 0.003), white (non-Hispanic) donor race (P = 0.002), and respiratory causes of donor death (P < 0.001). Among those without graft failure within the first postoperative year, the 5-year cumulative incidence (±95% confidence interval) of graft failure was 5% ± 5% in those with a 1-year CT ≤500 μm, 5% ± 3% for CT 501 to 550 μm, 7% ± 4% for CT 551 to 600 μm, and 20% ± 11% for CT >600 μm. In a multivariate analysis, both 1-year CT and cell density were associated with subsequent graft failure (P = 0.002 and 0.009). CT increase was modestly associated with endothelial cell loss during follow-up (r = -0.29). Conclusions: During the first 5 years after penetrating keratoplasty, CT can serve as a predictor of graft survival. However, CT is not a substitute for cell density measurement because both measures were independently predictive of graft failure.

AB - Purpose: To assess corneal thickness (CT) and correlation with graft outcome after penetrating keratoplasty in the Cornea Donor Study. Methods: A total of 887 subjects with a corneal transplant for a moderate-risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) had postoperative CT measurements throughout a 5-year follow-up time. Relationships between baseline (recipient, donor, and operative) factors and CT were explored. Proportional hazards models were used to assess the association between CT and graft failure. Relationship between CT and cell density was assessed with a longitudinal repeated measures model and Spearman correlation estimates. Results: Higher longitudinal CT measurements were associated with the following: diagnosis of pseudophakic or aphakic corneal edema (P < 0.001), intraocular pressure >25 mm Hg during the first postoperative month (P = 0.003), white (non-Hispanic) donor race (P = 0.002), and respiratory causes of donor death (P < 0.001). Among those without graft failure within the first postoperative year, the 5-year cumulative incidence (±95% confidence interval) of graft failure was 5% ± 5% in those with a 1-year CT ≤500 μm, 5% ± 3% for CT 501 to 550 μm, 7% ± 4% for CT 551 to 600 μm, and 20% ± 11% for CT >600 μm. In a multivariate analysis, both 1-year CT and cell density were associated with subsequent graft failure (P = 0.002 and 0.009). CT increase was modestly associated with endothelial cell loss during follow-up (r = -0.29). Conclusions: During the first 5 years after penetrating keratoplasty, CT can serve as a predictor of graft survival. However, CT is not a substitute for cell density measurement because both measures were independently predictive of graft failure.

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KW - Cornea transplantation

KW - Graft survival

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