Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration

Mary Utter, Anne J. Gemensky-Metzler, Nicole M. Scherrer, Riccardo Stoppini, Claire A. Latimer, Nicole E. Maclaren, Kathern E. Myrna

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To describe the clinical presentation, treatment, and outcome of a corneal dystrophy in Friesian horses and to analyze affected horses' pedigrees to investigate its heritability. Animals: Nine Friesians with bilateral disease were identified. Procedure: Retrospective medical record review was used to identify Friesian horses exhibiting bilateral symmetric corneal lesions. Variables identified from medical records included patient sex and age at diagnosis; location, depth and size of corneal lesions; medical and surgical therapy instituted; and visual outcome. A four-generation pedigree for each included horse was used to construct a combined pedigree. Results: The nine included horses had an average age at diagnosis of the first eye of 10.7 years, with males (8/9) significantly more frequently affected than females (1/9), P = 0.012. Lesions were inferior and averaged 5 mm in diameter. Depth ranged from superficial facets to perforations, which developed in nine of 18 eyes. Eight of nine perforations were surgically repaired, with seven of eight repaired eyes visual at last follow-up. All nine eyes that had not perforated remained visual. All affected horses shared a common ancestor within six generations. Conclusions: This form of corneal dystrophy in Friesian horses, characterized by bilateral symmetric stromal loss, appears to be progressive but responds well to surgical repair, occurs more frequently in males, may have a genetic component in Friesian horses, and may be a variant of pellucid marginal degeneration.

Original languageEnglish (US)
Pages (from-to)186-194
Number of pages9
JournalVeterinary Ophthalmology
Volume17
Issue numberSUPPL.1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Horses
horses
Pedigree
eyes
corneal diseases
pedigree
Medical Records
Friesian (horse breed)
lesions (animal)
ancestry
heritability
therapeutics
gender
animals

Keywords

  • Cornea
  • Dystrophy
  • Friesian
  • Pellucid marginal degeneration
  • Ulcer

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Utter, M., Gemensky-Metzler, A. J., Scherrer, N. M., Stoppini, R., Latimer, C. A., Maclaren, N. E., & Myrna, K. E. (2014). Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration. Veterinary Ophthalmology, 17(SUPPL.1), 186-194. https://doi.org/10.1111/vop.12152

Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration. / Utter, Mary; Gemensky-Metzler, Anne J.; Scherrer, Nicole M.; Stoppini, Riccardo; Latimer, Claire A.; Maclaren, Nicole E.; Myrna, Kathern E.

In: Veterinary Ophthalmology, Vol. 17, No. SUPPL.1, 01.01.2014, p. 186-194.

Research output: Contribution to journalArticle

Utter, M, Gemensky-Metzler, AJ, Scherrer, NM, Stoppini, R, Latimer, CA, Maclaren, NE & Myrna, KE 2014, 'Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration', Veterinary Ophthalmology, vol. 17, no. SUPPL.1, pp. 186-194. https://doi.org/10.1111/vop.12152
Utter M, Gemensky-Metzler AJ, Scherrer NM, Stoppini R, Latimer CA, Maclaren NE et al. Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration. Veterinary Ophthalmology. 2014 Jan 1;17(SUPPL.1):186-194. https://doi.org/10.1111/vop.12152
Utter, Mary ; Gemensky-Metzler, Anne J. ; Scherrer, Nicole M. ; Stoppini, Riccardo ; Latimer, Claire A. ; Maclaren, Nicole E. ; Myrna, Kathern E. / Corneal dystrophy in Friesian horses may represent a variant of pellucid marginal degeneration. In: Veterinary Ophthalmology. 2014 ; Vol. 17, No. SUPPL.1. pp. 186-194.
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