Core/shell quantum dots with high relaxivity and photoluminescence for multimodality imaging

Shizhong Wang, Benjamin R. Jarrett, Susan M. Kauzlarich, Angelique Y. Louie

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

A series of core/shell CdSe/Zn1-xMnxS nanoparticles were synthesized for use in dual-mode optical and magnetic resonance (MR) imaging techniques. Mn2+ content was in the range of 0.6-6.2% and varies with the thickness of the shell or amount of Mn2+ introduced to the reaction. These materials showed high quantum yield (QY), reaching 60% in organic solvent. Water-soluble nanoparticles were obtained by capping the core/shell particles with amphiphilic polymer, and the QY values in water reached 21%. These materials also demonstrated high relaxivity with r 1 values in the range of 11-18 mM-1 s-1 (at room temperature, 7 T). Both optical and MR imaging were performed on nanoparticles in aqueous solution and applied to cells in culture. The results showed that the QY and manganese concentration in the particles was sufficient to produce contrast for both modalities at relatively low concentrations of nanoparticles.

Original languageEnglish (US)
Pages (from-to)3848-3856
Number of pages9
JournalJournal of the American Chemical Society
Volume129
Issue number13
DOIs
StatePublished - Apr 4 2007

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Quantum Dots
Nanoparticles
Semiconductor quantum dots
Photoluminescence
Quantum yield
Imaging techniques
Magnetic resonance
Magnetic Resonance Imaging
Water
Manganese
Organic solvents
Polymers
Cell Culture Techniques
Temperature

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Core/shell quantum dots with high relaxivity and photoluminescence for multimodality imaging. / Wang, Shizhong; Jarrett, Benjamin R.; Kauzlarich, Susan M.; Louie, Angelique Y.

In: Journal of the American Chemical Society, Vol. 129, No. 13, 04.04.2007, p. 3848-3856.

Research output: Contribution to journalArticle

Wang, Shizhong ; Jarrett, Benjamin R. ; Kauzlarich, Susan M. ; Louie, Angelique Y. / Core/shell quantum dots with high relaxivity and photoluminescence for multimodality imaging. In: Journal of the American Chemical Society. 2007 ; Vol. 129, No. 13. pp. 3848-3856.
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