Corepressor diversification by alternative mRNA splicing is species specific

Martin L. Privalsky, Chelsea A. Snyder, Michael L. Goodson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: SMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another. Results: We report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution. Conclusions: We propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species.

Original languageEnglish (US)
Article number221
JournalBMC Evolutionary Biology
Volume16
Issue number1
DOIs
StatePublished - Oct 19 2016

Fingerprint

alternative splicing
convergent evolution
marsupial
teleost
reptile
hormone
carbohydrate
mammal
metabolism
lipid
bird
protein
mice
hormone receptors
carbohydrate metabolism
fish
Metatheria
lipid metabolism
reptiles
transcription factors

Keywords

  • Corepressor
  • Evolution
  • mRNA splicing
  • NCoR
  • SMRT

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Corepressor diversification by alternative mRNA splicing is species specific. / Privalsky, Martin L.; Snyder, Chelsea A.; Goodson, Michael L.

In: BMC Evolutionary Biology, Vol. 16, No. 1, 221, 19.10.2016.

Research output: Contribution to journalArticle

Privalsky, Martin L. ; Snyder, Chelsea A. ; Goodson, Michael L. / Corepressor diversification by alternative mRNA splicing is species specific. In: BMC Evolutionary Biology. 2016 ; Vol. 16, No. 1.
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