Copper supplementation in quaking mutant mice: Reduced tremors and increased brain copper

Carl L Keen, Lucille S. Hurley

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Mice homozygous for the mtutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the offspring. It is suggested that qk affects copper metabolism.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalScience
Volume193
Issue number4249
StatePublished - 1976

Fingerprint

Quaking Mice
Tremor
Copper
Brain
Lactation
Pregnancy
Genes

ASJC Scopus subject areas

  • General

Cite this

Copper supplementation in quaking mutant mice : Reduced tremors and increased brain copper. / Keen, Carl L; Hurley, Lucille S.

In: Science, Vol. 193, No. 4249, 1976, p. 244-246.

Research output: Contribution to journalArticle

Keen, CL & Hurley, LS 1976, 'Copper supplementation in quaking mutant mice: Reduced tremors and increased brain copper', Science, vol. 193, no. 4249, pp. 244-246.
Keen, Carl L ; Hurley, Lucille S. / Copper supplementation in quaking mutant mice : Reduced tremors and increased brain copper. In: Science. 1976 ; Vol. 193, No. 4249. pp. 244-246.
@article{30242714d1824cda8495f657e6ec496e,
title = "Copper supplementation in quaking mutant mice: Reduced tremors and increased brain copper",
abstract = "Mice homozygous for the mtutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the offspring. It is suggested that qk affects copper metabolism.",
author = "Keen, {Carl L} and Hurley, {Lucille S.}",
year = "1976",
language = "English (US)",
volume = "193",
pages = "244--246",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4249",

}

TY - JOUR

T1 - Copper supplementation in quaking mutant mice

T2 - Reduced tremors and increased brain copper

AU - Keen, Carl L

AU - Hurley, Lucille S.

PY - 1976

Y1 - 1976

N2 - Mice homozygous for the mtutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the offspring. It is suggested that qk affects copper metabolism.

AB - Mice homozygous for the mtutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the offspring. It is suggested that qk affects copper metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0017164894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017164894&partnerID=8YFLogxK

M3 - Article

C2 - 945613

AN - SCOPUS:0017164894

VL - 193

SP - 244

EP - 246

JO - Science

JF - Science

SN - 0036-8075

IS - 4249

ER -