Copper supplementation in quaking mutant mice: Reduced tremors and increased brain copper

Carl L Keen, Lucille S. Hurley

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Mice homozygous for the mtutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the offspring. It is suggested that qk affects copper metabolism.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalScience
Volume193
Issue number4249
StatePublished - 1976

ASJC Scopus subject areas

  • General

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