Copper status and adriamycin treatment: effects on antioxidant status in mice

Sheri Zidenberg-Cherr, Devon Dreith, Carl L Keen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalToxicology Letters
Volume48
Issue number2
DOIs
StatePublished - 1989

Keywords

  • Adriamycin
  • Antioxidants
  • Copper
  • Glutathione

ASJC Scopus subject areas

  • Toxicology

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