Abstract
The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
Original language | English (US) |
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Pages (from-to) | 201-212 |
Number of pages | 12 |
Journal | Toxicology Letters |
Volume | 48 |
Issue number | 2 |
DOIs | |
State | Published - 1989 |
Keywords
- Adriamycin
- Antioxidants
- Copper
- Glutathione
ASJC Scopus subject areas
- Toxicology