Abstract
The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-212 |
| Number of pages | 12 |
| Journal | Toxicology Letters |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1989 |
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Keywords
- Adriamycin
- Antioxidants
- Copper
- Glutathione
ASJC Scopus subject areas
- Toxicology
Cite this
Copper status and adriamycin treatment : effects on antioxidant status in mice. / Zidenberg-Cherr, Sheri; Dreith, Devon; Keen, Carl L.
In: Toxicology Letters, Vol. 48, No. 2, 1989, p. 201-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Copper status and adriamycin treatment
T2 - effects on antioxidant status in mice
AU - Zidenberg-Cherr, Sheri
AU - Dreith, Devon
AU - Keen, Carl L
PY - 1989
Y1 - 1989
N2 - The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
AB - The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
KW - Adriamycin
KW - Antioxidants
KW - Copper
KW - Glutathione
UR - http://www.scopus.com/inward/record.url?scp=0024346573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024346573&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(89)90175-6
DO - 10.1016/0378-4274(89)90175-6
M3 - Article
C2 - 2772926
AN - SCOPUS:0024346573
VL - 48
SP - 201
EP - 212
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 2
ER -