Copper status and adriamycin treatment: effects on antioxidant status in mice

Sheri Zidenberg-Cherr; Devon Dreith; Carl L Keen

doi:10.1016/0378-4274(89)90175-6

Copper status and adriamycin treatment: effects on antioxidant status in mice

Sheri Zidenberg-Cherr, Devon Dreith, Carl L Keen

Endocrinology, Diabetes, and Metabolism

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.

Original language	English (US)
Pages (from-to)	201-212
Number of pages	12
Journal	Toxicology Letters
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(89)90175-6
State	Published - 1989

Keywords

Adriamycin
Antioxidants
Copper
Glutathione

ASJC Scopus subject areas

Toxicology

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abstract = "The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.",

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T1 - Copper status and adriamycin treatment

T2 - effects on antioxidant status in mice

AU - Zidenberg-Cherr, Sheri

AU - Dreith, Devon

AU - Keen, Carl L

PY - 1989

Y1 - 1989

N2 - The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.

AB - The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.

KW - Adriamycin

KW - Antioxidants

KW - Copper

KW - Glutathione

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Copper status and adriamycin treatment: effects on antioxidant status in mice

Abstract

Keywords

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