Copper status and adriamycin treatment: effects on antioxidant status in mice

Sheri Zidenberg-Cherr, Devon Dreith, Carl L Keen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalToxicology Letters
Volume48
Issue number2
DOIs
StatePublished - 1989

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Doxorubicin
Copper
Antioxidants
Superoxide Dismutase
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Injections
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Glutathione
Tissue

Keywords

  • Adriamycin
  • Antioxidants
  • Copper
  • Glutathione

ASJC Scopus subject areas

  • Toxicology

Cite this

Copper status and adriamycin treatment : effects on antioxidant status in mice. / Zidenberg-Cherr, Sheri; Dreith, Devon; Keen, Carl L.

In: Toxicology Letters, Vol. 48, No. 2, 1989, p. 201-212.

Research output: Contribution to journalArticle

Zidenberg-Cherr, Sheri ; Dreith, Devon ; Keen, Carl L. / Copper status and adriamycin treatment : effects on antioxidant status in mice. In: Toxicology Letters. 1989 ; Vol. 48, No. 2. pp. 201-212.
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