Abstract
The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac Superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-212 |
| Number of pages | 12 |
| Journal | Toxicology Letters |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1989 |
Keywords
- Adriamycin
- Antioxidants
- Copper
- Glutathione
ASJC Scopus subject areas
- Toxicology
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Zidenberg-Cherr, S., Dreith, D., & Keen, C. L. (1989). Copper status and adriamycin treatment: effects on antioxidant status in mice. Toxicology Letters, 48(2), 201-212. https://doi.org/10.1016/0378-4274(89)90175-6