Copper oxide wire particles for the treatment of copper deficiency in sheep

A. León, J. S. Glenn, Thomas B Farver

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Copper plays an important role in physiological and biochemical systems of animals. Copper deficiency in sheep produces ataxia, changes in color of pigmented wool, anemia, diarrhea and weight loss and is a major concern in the sheep industry because of indirect economic losses. There are several treatments against this disease but each of them has problems associated with usage. There is not an approved product for sheep in the United States for this deficiency. The efficacy of two copper oxide wire products (Coppinox® and Copasure®) were tested in a flock of sheep with known deficiency. Three groups of 10 animals each, were used in a randomized block design. Animals were blocked by age. One group was dosed with 4 g of Coppinox, one with 4 g of Copasure and the third was left as an untreated control. Serum samples were taken monthly and copper levels were measured. The initial mean and range for all the animals on the study was 0.667 PPM and 0.16-1.06 PPM. The treated groups presented an increase in the mean copper serum concentration above the normal level (0.8 PPM) for five months. The untreated group had a mean below 0.8 PPM during the trial and showed clinical manifestation of the disease. None of the treated animals had clinical signs of copper deficiency or copper intoxication. Both formulations were efficient and safe for treatment of copper deficiency in sheep.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalSmall Ruminant Research
Issue number1
StatePublished - 1999


  • Copper
  • Copper oxide wire
  • Deficiency
  • Sheep

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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