Copper nitrilotriacetate: A potent therapeutic agent in the treatment of a genetic disorder of copper metabolism

Carl L Keen, P. Saltman, L. S. Hurley

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Copper nitrilotriacetate (NTA) was evaluated for its ability to ameliorate effects of the recessive mutant gene crinkled (cr) in mice. Copper-NTA was superior to copper sulfate in increasing postnatal survival and body copper content of offspring of dams supplemented during pregnancy and lactation. Feeding of NTA alone during these periods had no effect on survival. Postnatal supplementation with copper did not increase survival of the mutants. The therapeutic use of copper-NTA, and the necessity for prenatal intervention for successful treatment of the mutant, are discussed in relation to Menkes' syndrome.

Original languageEnglish (US)
Pages (from-to)1789-1800
Number of pages12
JournalAmerican Journal of Clinical Nutrition
Volume33
Issue number8
StatePublished - 1980

Fingerprint

Inborn Genetic Diseases
genetic disorders
Copper
copper
therapeutics
mutants
Menkes Kinky Hair Syndrome
Copper Sulfate
Recessive Genes
Therapeutics
copper sulfate
Therapeutic Uses
Lactation
lactation
copper metabolism
pregnancy
Pregnancy
mice
genes

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Copper nitrilotriacetate : A potent therapeutic agent in the treatment of a genetic disorder of copper metabolism. / Keen, Carl L; Saltman, P.; Hurley, L. S.

In: American Journal of Clinical Nutrition, Vol. 33, No. 8, 1980, p. 1789-1800.

Research output: Contribution to journalArticle

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