Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts

Zhiming Liao, John Allred, Carl L Keen, Sylvia A. McCune, Robert B. Rucker, Denis M. Medeiros

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The relative amounts of carddac proteins such as laminin, fibronectin, cytochrome c oxidase, and isomyosin types were studied by gel electrophoresis and Western blotting in control and copper-deficient Sprague-Dawley rats of both sexes fed their respective diets from weanling for 3 weeks. Isomyosin types appeared to shift from V1 to greater levels of V3 in copper deficient rats for both genders. Male copper deficient rats had increased cardiac levels of fibronectin, decreased laminin levels, cardiac hypertrophy and anemia. Both male and female rats fed copper-deficient diet had lower levels of cytochrome c oxidase (CCO) subunit IV, and low liver copper, and high heart-to-body weight ratios compared with their respective controls.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume111
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Laminin
Electron Transport Complex IV
Fibronectins
Rats
Copper
Nutrition
Diet
Cardiomegaly
Electrophoresis
Liver
Sprague Dawley Rats
Anemia
Western Blotting
Gels
Body Weight
Proteins

Keywords

  • Basal lamina
  • Cardiac
  • Copper-deficiency
  • Cytochrome c oxidase
  • Fibronectin
  • Laminin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology

Cite this

Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts. / Liao, Zhiming; Allred, John; Keen, Carl L; McCune, Sylvia A.; Rucker, Robert B.; Medeiros, Denis M.

In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Vol. 111, No. 1, 1995, p. 61-67.

Research output: Contribution to journalArticle

Liao, Zhiming ; Allred, John ; Keen, Carl L ; McCune, Sylvia A. ; Rucker, Robert B. ; Medeiros, Denis M. / Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts. In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 1995 ; Vol. 111, No. 1. pp. 61-67.
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