TY - JOUR
T1 - Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defense in weanling rats
AU - Olin, Katherine L.
AU - Walter, Robert M.
AU - Keen, Carl L
PY - 1994/3
Y1 - 1994/3
N2 - Copper deficiency has been postulated to result in low selenoglutathione peroxidase (Se-GSHPx) activity, secondary to alterations in the antioxidant defense system. Type I iodothyronine 5'-deiodinase contains selenium; because it is not part of the antioxidant defense system its measurement provides a way to evaluate the influence of copper on selenoenzymes independent of the antioxidant system. Weanling rats were fed the control diet (125.9 nmol Cu/g diet), copper-deficient diet (7.9 nmol Cu/g diet), or the control diet restricted to the intake of the deficient rats (restrict-fed), for 21 d. Rats fed the copper-deficient diet had cardiomegaly, low hematocrit values, and low tissue copper concentrations, but normal liver selenium concentrations. Liver and plasma Se-GSHPx activities were lowest in the deficient rats. Non- Se-GSHPx activity was similar between control and copper-deficient groups. Liver selenodeiodinase activity was lowest in the copper-deficient rats; this reduction was functionally significant as evidenced by low plasma 3,3',5- triiodothyronine and high plasma 3,3',5'-triiodothyronine concentrations.
AB - Copper deficiency has been postulated to result in low selenoglutathione peroxidase (Se-GSHPx) activity, secondary to alterations in the antioxidant defense system. Type I iodothyronine 5'-deiodinase contains selenium; because it is not part of the antioxidant defense system its measurement provides a way to evaluate the influence of copper on selenoenzymes independent of the antioxidant system. Weanling rats were fed the control diet (125.9 nmol Cu/g diet), copper-deficient diet (7.9 nmol Cu/g diet), or the control diet restricted to the intake of the deficient rats (restrict-fed), for 21 d. Rats fed the copper-deficient diet had cardiomegaly, low hematocrit values, and low tissue copper concentrations, but normal liver selenium concentrations. Liver and plasma Se-GSHPx activities were lowest in the deficient rats. Non- Se-GSHPx activity was similar between control and copper-deficient groups. Liver selenodeiodinase activity was lowest in the copper-deficient rats; this reduction was functionally significant as evidenced by low plasma 3,3',5- triiodothyronine and high plasma 3,3',5'-triiodothyronine concentrations.
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M3 - Article
C2 - 8116544
AN - SCOPUS:0028209366
VL - 59
SP - 654
EP - 658
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -