Coordination of nuclear- and mitochondrial-DNA encoded proteins in cancer and normal colon tissues

Roberto Mazzanti, Cecilia R Giulivi

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

To support the rapid growth of tumors, the cell can respond by increasing the number of mitochondria, in a concerted biosynthesis of mitochondrial constituents (nuclear and mitochondria encoded). Increased transcription, availability and stability of oxidative phosphorylation mRNAs, without increasing mitochondria number could also lead to more rapid energy-yielding effects. Mitochondria biogenesis and de novo formation of respiratory chain components imply coordination of nuclear and mt gene transcription. The mitochondrial mass is regulated by a number of physiopathological conditions. In response to external stimuli, mitochondria biogenesis is dependent on an orchestrated crosstalk between the nuclear and the mitochondrial genomes. Based on the higher incidence of glycolysis over oxidative phosphorylation in cancer tissues, we studied by differential proteomics the energy metabolism pathway of matched samples of normal and cancer tissue. Our results indicated that oxidative phosphorylation in cancer cells seemed altered because there is an unbalanced coordination between nuclear- and mitochondria-encoded mitochondrial proteins.

Original languageEnglish (US)
Pages (from-to)618-623
Number of pages6
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1757
Issue number5-6
DOIs
StatePublished - May 2006

Keywords

  • Bioenergetics
  • Cancer
  • Differential expression
  • Mitochondria
  • Proteomics

ASJC Scopus subject areas

  • Biophysics

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