Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

Jennifer C. King, Jin Xu, John Wongvipat, Haley Hieronymus, Brett S. Carver, David H. Leung, Barry S. Taylor, Chris Sander, Robert Cardiff, Suzana S. Couto, William L. Gerald, Charles L. Sawyers

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329 Citations (Scopus)

Abstract

The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.

Original languageEnglish (US)
Pages (from-to)524-526
Number of pages3
JournalNature Genetics
Volume41
Issue number5
DOIs
StatePublished - May 1 2009

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Prostatic Intraepithelial Neoplasia
Phosphatidylinositol 3-Kinases
Prostate
Carcinogenesis
Prostatic Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

King, J. C., Xu, J., Wongvipat, J., Hieronymus, H., Carver, B. S., Leung, D. H., ... Sawyers, C. L. (2009). Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nature Genetics, 41(5), 524-526. https://doi.org/10.1038/ng.371

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. / King, Jennifer C.; Xu, Jin; Wongvipat, John; Hieronymus, Haley; Carver, Brett S.; Leung, David H.; Taylor, Barry S.; Sander, Chris; Cardiff, Robert; Couto, Suzana S.; Gerald, William L.; Sawyers, Charles L.

In: Nature Genetics, Vol. 41, No. 5, 01.05.2009, p. 524-526.

Research output: Contribution to journalArticle

King, JC, Xu, J, Wongvipat, J, Hieronymus, H, Carver, BS, Leung, DH, Taylor, BS, Sander, C, Cardiff, R, Couto, SS, Gerald, WL & Sawyers, CL 2009, 'Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis', Nature Genetics, vol. 41, no. 5, pp. 524-526. https://doi.org/10.1038/ng.371
King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nature Genetics. 2009 May 1;41(5):524-526. https://doi.org/10.1038/ng.371
King, Jennifer C. ; Xu, Jin ; Wongvipat, John ; Hieronymus, Haley ; Carver, Brett S. ; Leung, David H. ; Taylor, Barry S. ; Sander, Chris ; Cardiff, Robert ; Couto, Suzana S. ; Gerald, William L. ; Sawyers, Charles L. / Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. In: Nature Genetics. 2009 ; Vol. 41, No. 5. pp. 524-526.
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