Conversion disorder in women with the FMR1 premutation

Andreea L. Seritan, Andrea Schneider, John M Olichney, Maureen A. Leehey, R. Scott Akins, Randi J Hagerman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.

Original languageEnglish (US)
Pages (from-to)2501-2506
Number of pages6
JournalAmerican Journal of Medical Genetics, Part A
Volume149
Issue number11
DOIs
StatePublished - Nov 2009

Keywords

  • Conversion
  • FMR1 premutation
  • Psychogenic nonepileptic seizures

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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