Conversion disorder in women with the FMR1 premutation

Andreea L. Seritan; Andrea Schneider; John M Olichney; Maureen A. Leehey; R. Scott Akins; Randi J Hagerman

doi:10.1002/ajmg.a.33054

Conversion disorder in women with the FMR1 premutation

Andreea L. Seritan, Andrea Schneider, John M Olichney, Maureen A. Leehey, R. Scott Akins, Randi J Hagerman

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.

Original language	English (US)
Pages (from-to)	2501-2506
Number of pages	6
Journal	American Journal of Medical Genetics, Part A
Volume	149
Issue number	11
DOIs	https://doi.org/10.1002/ajmg.a.33054
State	Published - Nov 2009

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Keywords

Conversion
FMR1 premutation
Psychogenic nonepileptic seizures

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

Seritan, A. L., Schneider, A., Olichney, J. M., Leehey, M. A., Akins, R. S., & Hagerman, R. J. (2009). Conversion disorder in women with the FMR1 premutation. American Journal of Medical Genetics, Part A, 149(11), 2501-2506. https://doi.org/10.1002/ajmg.a.33054

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10.1002/ajmg.a.33054