Conversion disorder in women with the FMR1 premutation

Andreea L. Seritan; Andrea Schneider; John M Olichney; Maureen A. Leehey; R. Scott Akins; Randi J Hagerman

doi:10.1002/ajmg.a.33054

Conversion disorder in women with the FMR1 premutation

Andreea L. Seritan, Andrea Schneider, John M Olichney, Maureen A. Leehey, R. Scott Akins, Randi J Hagerman

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.

Original language	English (US)
Pages (from-to)	2501-2506
Number of pages	6
Journal	American Journal of Medical Genetics, Part A
Volume	149
Issue number	11
DOIs	https://doi.org/10.1002/ajmg.a.33054
State	Published - Nov 2009

Keywords

Conversion
FMR1 premutation
Psychogenic nonepileptic seizures

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Access to Document

10.1002/ajmg.a.33054

Cite this

@article{01c797912c7848459a62c63bb2491741,

title = "Conversion disorder in women with the FMR1 premutation",

abstract = "Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.",

keywords = "Conversion, FMR1 premutation, Psychogenic nonepileptic seizures",

author = "Seritan, {Andreea L.} and Andrea Schneider and Olichney, {John M} and Leehey, {Maureen A.} and Akins, {R. Scott} and Hagerman, {Randi J}",

year = "2009",

month = nov,

doi = "10.1002/ajmg.a.33054",

language = "English (US)",

volume = "149",

pages = "2501--2506",

journal = "American Journal of Medical Genetics",

issn = "1552-4825",

publisher = "Wiley-Liss Inc.",

number = "11",

}

TY - JOUR

T1 - Conversion disorder in women with the FMR1 premutation

AU - Seritan, Andreea L.

AU - Schneider, Andrea

AU - Olichney, John M

AU - Leehey, Maureen A.

AU - Akins, R. Scott

AU - Hagerman, Randi J

PY - 2009/11

Y1 - 2009/11

N2 - Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.

AB - Women with fragile X mental retardation (FMR1) gene premutations (55-200 CGG repeats) were until recently believed to be unaffected. It is now known that up to 8% of older female FMR1 premutation carriers develop fragile X-associated tremor/ataxia syndrome (FXTAS). Female carriers may also develop primary ovarian insufficiency, thyroid disease, hypertension, seizures, peripheral neuropathy, and fibromyalgia. We present a 60-yearold woman with FMR1 premutation who had depression, anxiety, and conversion disorder with seizures. The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity.

KW - Conversion

KW - FMR1 premutation

KW - Psychogenic nonepileptic seizures

UR - http://www.scopus.com/inward/record.url?scp=70449441433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449441433&partnerID=8YFLogxK

U2 - 10.1002/ajmg.a.33054

DO - 10.1002/ajmg.a.33054

M3 - Article

C2 - 19842197

AN - SCOPUS:70449441433

VL - 149

SP - 2501

EP - 2506

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 1552-4825

IS - 11

ER -

Conversion disorder in women with the FMR1 premutation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this