Conventional and future diagnostics for avian influenza

Bruce Charlton, Beate Crossley, Sharon Hietala

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The significant and continued transboundary spread of Asian avian influenza H5N1 since 2003, paired with documented transmission from avian species to humans and other mammals, has focused global attention on avian influenza virus detection and diagnostic strategies. While the historic and conventional laboratory methods used for isolation and identification of the virus and for detection of specific antibodies continued to be widely applied, new and emerging technologies are rapidly being adapted to support avian influenza virus surveillance and diagnosis worldwide. Molecular tools in particular are advancing toward lab-on-chip and fully integrated technologies that are capable of same day detection, pathotyping, and phylogenetic characterization of influenza A viruses obtained from clinical specimens. The future of avian influenza diagnostics, rather than moving toward a single approach, is wisely adopting a strategy that takes advantage of the range of conventional and advancing technologies to be used in "fit-for-purpose" testing.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume32
Issue number4
DOIs
StatePublished - Jul 2009

Keywords

  • "Fit-for-purpose"
  • Avian influenza
  • Detection
  • Diagnosis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases
  • Immunology and Allergy
  • veterinary(all)

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