Controversies in the treatment of sepsis

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32 Scopus citations


Sepsis is a common illness of intensive care unit patients that carries a high morbidity, mortality, and increases hospital cost. Although mortality from sepsis remains high when compared with other critical illnesses, it has declined over the last few decades due to several adjunctive therapies and focused care programs or guidelines. Many interventions, such as early appropriate antibiotic therapy and lung protective, low tidal volume ventilation are commonplace and carry little controversy in their benefit. However, other therapies still have an unclear benefit and remain controversial. This article discusses the controversial roles of intensive insulin therapy, corticosteroids, and activated protein C in the treatment of sepsis.

Original languageEnglish (US)
Pages (from-to)66-78
Number of pages13
JournalSeminars in Respiratory and Critical Care Medicine
Issue number1
StatePublished - 2010


  • Activated protein C
  • Corticosteroids
  • Glucose control
  • Insulin
  • Sepsis
  • Septic shock

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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