Controlling oxygen gradients within microfluidic devices to study angiogenesis

Sandra F. Lam, Yunli E. Chu, Alan G. Soetikno, Steven C. George

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hypoxia is an important feature of physiology as even during early development the formation of vasculature is required to deliver oxygen and nutrients to other organs. Here, we have created a microfluidic device that can manipulate and measure the oxygen tension to better understand phenomena such as angiogenesis, or the formation of new vasculature form an existing network. With our device, we created an oxygen gradient and confirmed this gradient by measuring the actual oxygen tension using a phosphorescent lifetime imaging microscopy technique. Lastly, with the successful completion of our platform, we were able to observe how hypoxic fibroblasts can bias the formation of new vessel growth.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1055-1056
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • Angiogenesis
  • Hypoxia
  • PhLIM

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Lam, S. F., Chu, Y. E., Soetikno, A. G., & George, S. C. (2020). Controlling oxygen gradients within microfluidic devices to study angiogenesis. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1055-1056). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.