Abstract
Direct-current (DC) electric fields are present in all developing and regenerating animal tissues, yet their existence and potential impact on tissue repair and development are largely ignored. This is primarily due to ignorance of the phenomenon by most researchers, some technically poor early studies of the effects of applied fields on cells, and widespread misunderstanding of the fundamental concepts that underlie bioelectricity. This review aims to resolve these issues by describing: 7) the historical context of bioelectricity, 2) the fundamental principles of physics and physiology responsible for DC electric fields within cells and tissues, 3) the cellular mechanisms for the effects of small electric fields on cell behavior, and 4) the clinical potential for electric field treatment of damaged tissues such as epithelia and the nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 943-978 |
| Number of pages | 36 |
| Journal | Physiological Reviews |
| Volume | 85 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
Cite this
Controlling cell behavior electrically : Current views and future potential. / McCaig, Colin D.; Rajnicek, Ann M.; Song, Bing; Zhao, Min.
In: Physiological Reviews, Vol. 85, No. 3, 07.2005, p. 943-978.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Controlling cell behavior electrically
T2 - Current views and future potential
AU - McCaig, Colin D.
AU - Rajnicek, Ann M.
AU - Song, Bing
AU - Zhao, Min
PY - 2005/7
Y1 - 2005/7
N2 - Direct-current (DC) electric fields are present in all developing and regenerating animal tissues, yet their existence and potential impact on tissue repair and development are largely ignored. This is primarily due to ignorance of the phenomenon by most researchers, some technically poor early studies of the effects of applied fields on cells, and widespread misunderstanding of the fundamental concepts that underlie bioelectricity. This review aims to resolve these issues by describing: 7) the historical context of bioelectricity, 2) the fundamental principles of physics and physiology responsible for DC electric fields within cells and tissues, 3) the cellular mechanisms for the effects of small electric fields on cell behavior, and 4) the clinical potential for electric field treatment of damaged tissues such as epithelia and the nervous system.
AB - Direct-current (DC) electric fields are present in all developing and regenerating animal tissues, yet their existence and potential impact on tissue repair and development are largely ignored. This is primarily due to ignorance of the phenomenon by most researchers, some technically poor early studies of the effects of applied fields on cells, and widespread misunderstanding of the fundamental concepts that underlie bioelectricity. This review aims to resolve these issues by describing: 7) the historical context of bioelectricity, 2) the fundamental principles of physics and physiology responsible for DC electric fields within cells and tissues, 3) the cellular mechanisms for the effects of small electric fields on cell behavior, and 4) the clinical potential for electric field treatment of damaged tissues such as epithelia and the nervous system.
UR - http://www.scopus.com/inward/record.url?scp=21244445821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21244445821&partnerID=8YFLogxK
U2 - 10.1152/physrev.00020.2004
DO - 10.1152/physrev.00020.2004
M3 - Article
C2 - 15987799
AN - SCOPUS:21244445821
VL - 85
SP - 943
EP - 978
JO - Physiological Reviews
JF - Physiological Reviews
SN - 0031-9333
IS - 3
ER -