Abstract
Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.
Original language | English (US) |
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Pages (from-to) | 23128-23140 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 32 |
DOIs | |
State | Published - Aug 9 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology