Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion

Mette V. Jensen, Jonathan M. Haldeman, Hengtao Zhang, Danhong Lu, Mark O. Huising, Wylie W. Vale, Hans E. Hohmeier, Paul Rosenberg, Christopher B. Newgard

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)23128-23140
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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