Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion

Mette V. Jensen; Jonathan M. Haldeman; Hengtao Zhang; Danhong Lu; Mark O. Huising; Wylie W. Vale; Hans E. Hohmeier; Paul Rosenberg; Christopher B. Newgard

doi:10.1074/jbc.M113.491654

Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion

Mette V. Jensen, Jonathan M. Haldeman, Hengtao Zhang, Danhong Lu, Mark O. Huising, Wylie W. Vale, Hans E. Hohmeier, Paul Rosenberg, Christopher B. Newgard

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.

Original language	English (US)
Pages (from-to)	23128-23140
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.491654
State	Published - Aug 9 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Jensen, M. V., Haldeman, J. M., Zhang, H., Lu, D., Huising, M. O., Vale, W. W., Hohmeier, H. E., Rosenberg, P., & Newgard, C. B. (2013). Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. Journal of Biological Chemistry, 288(32), 23128-23140. https://doi.org/10.1074/jbc.M113.491654

Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. / Jensen, Mette V.; Haldeman, Jonathan M.; Zhang, Hengtao; Lu, Danhong; Huising, Mark O.; Vale, Wylie W.; Hohmeier, Hans E.; Rosenberg, Paul; Newgard, Christopher B.

In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 23128-23140.

Research output: Contribution to journal › Article › peer-review

Jensen, Mette V. ; Haldeman, Jonathan M. ; Zhang, Hengtao ; Lu, Danhong ; Huising, Mark O. ; Vale, Wylie W. ; Hohmeier, Hans E. ; Rosenberg, Paul ; Newgard, Christopher B. / Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 23128-23140.

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abstract = "Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.",

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AU - Haldeman, Jonathan M.

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AU - Lu, Danhong

AU - Huising, Mark O.

AU - Vale, Wylie W.

AU - Hohmeier, Hans E.

AU - Rosenberg, Paul

AU - Newgard, Christopher B.

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N2 - Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.

AB - Background: Pyruvate-isocitrate cycling is involved in control of glucose-stimulated insulin secretion (GSIS), but the underlying mechanisms are unknown. Results: Pyruvate-isocitrate cycling controls expression of the voltage-gated potassium channel family member Kv2.2 in islet cells. Conclusion: Pyruvate-isocitrate cycling maintains Kv2.2 expression, allowing it to serve as a negative regulator of Kv channel activity. Significance: Kv2.2 is a potential new target for reversing β-cell dysfunction of type 2 diabetes.

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Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion

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