Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats

Benjamin Hart, Kelly D. Cliff, Valarie V. Tynes, Laurie Bergman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives - To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated > 8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated > 8 weeks; and whether cats that are successfully treated but resume marking after drug withdrawal can be successfully treated again with the same drug regimen. Design - Positive-controlled, double-masked clinical trial. Animals - 22 neutered cats (2 females, 20 males) ≥ 1 year old with objectionable urine marking. Procedure - Cats that marked vertically ≥ 3 times/wk were treated with fluoxetine (1 mg/kg [0.45 mg/lb], q 24 h, PO) or clomipramine (0.5 mg/kg [0.23 mg/lb], q 24 h, PO) for 16 weeks, and efficacy was compared. Recurrence of marking was determined after abrupt withdrawal of fluoxetine at 16 or 32 weeks. Reduction in marking in cats treated with fluoxetine for 8 weeks after returning to marking following drug withdrawal was compared with the initial 8 weeks of successful treatment. Results - Efficacy of fluoxetine and clomipramine was similar. Treatment > 8 weeks revealed increasing efficacy in reduction of marking. Return of marking after termination of fluoxetine administration occurred in most cats. Cats successfully treated initially with fluoxetine responded similarly to repeated treatment. Conclusions and Clinical Relevance - Clomipramine and fluoxetine were equivalent in treating urine marking. Longer treatment increased efficacy. Most cats return to marking after abrupt drug withdrawal. A second course of treatment can be expected to be as effective as the first.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume226
Issue number3
DOIs
StatePublished - Feb 1 2005

Fingerprint

Clomipramine
Fluoxetine
Cats
urine
Urine
cats
drugs
Pharmaceutical Preparations
Recurrence
Felidae
clinical trials
Clinical Trials

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats. / Hart, Benjamin; Cliff, Kelly D.; Tynes, Valarie V.; Bergman, Laurie.

In: Journal of the American Veterinary Medical Association, Vol. 226, No. 3, 01.02.2005, p. 378-382.

Research output: Contribution to journalArticle

@article{f6cda97a943b43f39bbba474e37cfadf,
title = "Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats",
abstract = "Objectives - To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated > 8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated > 8 weeks; and whether cats that are successfully treated but resume marking after drug withdrawal can be successfully treated again with the same drug regimen. Design - Positive-controlled, double-masked clinical trial. Animals - 22 neutered cats (2 females, 20 males) ≥ 1 year old with objectionable urine marking. Procedure - Cats that marked vertically ≥ 3 times/wk were treated with fluoxetine (1 mg/kg [0.45 mg/lb], q 24 h, PO) or clomipramine (0.5 mg/kg [0.23 mg/lb], q 24 h, PO) for 16 weeks, and efficacy was compared. Recurrence of marking was determined after abrupt withdrawal of fluoxetine at 16 or 32 weeks. Reduction in marking in cats treated with fluoxetine for 8 weeks after returning to marking following drug withdrawal was compared with the initial 8 weeks of successful treatment. Results - Efficacy of fluoxetine and clomipramine was similar. Treatment > 8 weeks revealed increasing efficacy in reduction of marking. Return of marking after termination of fluoxetine administration occurred in most cats. Cats successfully treated initially with fluoxetine responded similarly to repeated treatment. Conclusions and Clinical Relevance - Clomipramine and fluoxetine were equivalent in treating urine marking. Longer treatment increased efficacy. Most cats return to marking after abrupt drug withdrawal. A second course of treatment can be expected to be as effective as the first.",
author = "Benjamin Hart and Cliff, {Kelly D.} and Tynes, {Valarie V.} and Laurie Bergman",
year = "2005",
month = "2",
day = "1",
doi = "10.2460/javma.2005.226.378",
language = "English (US)",
volume = "226",
pages = "378--382",
journal = "Journal of the American Veterinary Medical Association",
issn = "0003-1488",
publisher = "American Veterinary Medical Association",
number = "3",

}

TY - JOUR

T1 - Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats

AU - Hart, Benjamin

AU - Cliff, Kelly D.

AU - Tynes, Valarie V.

AU - Bergman, Laurie

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Objectives - To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated > 8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated > 8 weeks; and whether cats that are successfully treated but resume marking after drug withdrawal can be successfully treated again with the same drug regimen. Design - Positive-controlled, double-masked clinical trial. Animals - 22 neutered cats (2 females, 20 males) ≥ 1 year old with objectionable urine marking. Procedure - Cats that marked vertically ≥ 3 times/wk were treated with fluoxetine (1 mg/kg [0.45 mg/lb], q 24 h, PO) or clomipramine (0.5 mg/kg [0.23 mg/lb], q 24 h, PO) for 16 weeks, and efficacy was compared. Recurrence of marking was determined after abrupt withdrawal of fluoxetine at 16 or 32 weeks. Reduction in marking in cats treated with fluoxetine for 8 weeks after returning to marking following drug withdrawal was compared with the initial 8 weeks of successful treatment. Results - Efficacy of fluoxetine and clomipramine was similar. Treatment > 8 weeks revealed increasing efficacy in reduction of marking. Return of marking after termination of fluoxetine administration occurred in most cats. Cats successfully treated initially with fluoxetine responded similarly to repeated treatment. Conclusions and Clinical Relevance - Clomipramine and fluoxetine were equivalent in treating urine marking. Longer treatment increased efficacy. Most cats return to marking after abrupt drug withdrawal. A second course of treatment can be expected to be as effective as the first.

AB - Objectives - To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated > 8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated > 8 weeks; and whether cats that are successfully treated but resume marking after drug withdrawal can be successfully treated again with the same drug regimen. Design - Positive-controlled, double-masked clinical trial. Animals - 22 neutered cats (2 females, 20 males) ≥ 1 year old with objectionable urine marking. Procedure - Cats that marked vertically ≥ 3 times/wk were treated with fluoxetine (1 mg/kg [0.45 mg/lb], q 24 h, PO) or clomipramine (0.5 mg/kg [0.23 mg/lb], q 24 h, PO) for 16 weeks, and efficacy was compared. Recurrence of marking was determined after abrupt withdrawal of fluoxetine at 16 or 32 weeks. Reduction in marking in cats treated with fluoxetine for 8 weeks after returning to marking following drug withdrawal was compared with the initial 8 weeks of successful treatment. Results - Efficacy of fluoxetine and clomipramine was similar. Treatment > 8 weeks revealed increasing efficacy in reduction of marking. Return of marking after termination of fluoxetine administration occurred in most cats. Cats successfully treated initially with fluoxetine responded similarly to repeated treatment. Conclusions and Clinical Relevance - Clomipramine and fluoxetine were equivalent in treating urine marking. Longer treatment increased efficacy. Most cats return to marking after abrupt drug withdrawal. A second course of treatment can be expected to be as effective as the first.

UR - http://www.scopus.com/inward/record.url?scp=12744263247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12744263247&partnerID=8YFLogxK

U2 - 10.2460/javma.2005.226.378

DO - 10.2460/javma.2005.226.378

M3 - Article

VL - 226

SP - 378

EP - 382

JO - Journal of the American Veterinary Medical Association

JF - Journal of the American Veterinary Medical Association

SN - 0003-1488

IS - 3

ER -