Abstract
Thioalkyl and thioalkylated oligo(ethylene glycol) (OEG) ligands with chain-end functionality were used to fabricate water-soluble CdSe nanoparticle scaffolds. Surface recognition of chymotrypsin (ChT) was achieved using these functionalized nanoparticle scaffolds, with three levels of interaction demonstrated: no interaction (OEG terminated with hydroxyl group), inhibition with denaturation (carboxylate-terminated thioalkyl ligands), and inhibition with retention of structure (carboxylate-terminated OEG). The latter process was reversible upon an increase in ionic strength, with essentially complete restoration of enzymatic activity.
Original language | English (US) |
---|---|
Pages (from-to) | 739-743 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 126 |
Issue number | 3 |
DOIs | |
State | Published - Jan 28 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Chemistry(all)