Control of asymmetric cell division in early C. elegans embryogenesis: Teaming-up translational repression and protein degradation

Sue Yun Hwang, Lesilee S. Rose

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Asymmetric cell division is a fundamental mechanism for the generation of body axes and cell diversity during early embryogenesis in many organisms. During intrinsically asymmetric divisions, an axis of polarity is established within the cell and the division plane is oriented to ensure the differential segregation of developmental determinants to the daughter cells. Studies in the nematode Caenorhabditis elegans have contributed greatly to our understanding of the regulatory mechanisms underlying cell polarity and asymmetric division. However, much remains to be elucidated about the molecular machinery controlling the spatiotemporal distribution of key components. In this review we discuss recent findings that reveal intricate interactions between translational control and targeted proteolysis. These two mechanisms of regulation serve to carefully modulate protein levels and reinforce asymmetries, or to eliminate proteins from certain cells.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalBMB Reports
Volume43
Issue number2
StatePublished - Feb 2010

Keywords

  • Asymmetric division
  • Caenorhabditis elegans
  • PAR proteins
  • Translational control
  • Ubiquitin proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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