Contributions of temporal-parietal junction to the human auditory P3

Robert T. Knight, Donatella Scabini, David L Woods, Clay C. Clayworth

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

The P3 component of the event-related potential (ERP) is generated in humans and other mammalian species when attention is drawn to infrequent stimuli. We assessed the role of subregions of human posterior association cortex in auditory P3 generation in groups of patients with focal cortical lesions. Auditory P3s were recorded to target (P3b) and unexpected novel stimuli (P3a) in monaural and dichotic signal detection experiments. Two groups of patients were studied with lesions of: (1) temporal-parietal junction including posterior superior temporal plane and adjacent caudal inferior parietal cortex; and (2) the lateral parietal lobe including the rostral inferior parietal lobe and portions of superior parietal lobe. Extensive lateral parietal cortex lesions had no effect on the P3. In contrast, discrete unilateral lesions centered in the posterior superior temporal plane eliminated both the auditory P3b and P3a at electrodes over the posterior scalp. The results indicate that auditory association cortex in the human temporal-parietal junction is critical for auditory P3 generation.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalBrain Research
Volume502
Issue number1
DOIs
StatePublished - Nov 13 1989

Fingerprint

Parietal Lobe
Auditory Cortex
P300 Event-Related Potentials
Scalp
Electrodes

Keywords

  • Area cSTP
  • Area Tpt
  • Attention
  • Memory
  • Orientation
  • P3
  • Temporal-parietal

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Contributions of temporal-parietal junction to the human auditory P3. / Knight, Robert T.; Scabini, Donatella; Woods, David L; Clayworth, Clay C.

In: Brain Research, Vol. 502, No. 1, 13.11.1989, p. 109-116.

Research output: Contribution to journalArticle

Knight, Robert T. ; Scabini, Donatella ; Woods, David L ; Clayworth, Clay C. / Contributions of temporal-parietal junction to the human auditory P3. In: Brain Research. 1989 ; Vol. 502, No. 1. pp. 109-116.
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