Contribution of vagal afferents to breathing pattern in rats with lung fibrosis

Jim K. Mansoor, Dallas M. Hyde, Edward S Schelegle

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In anesthestized male Wistar rats with bleomycin-induced lung fibrosis we examined the influence of lung vagal non-myelinated and myelinated afferents in setting breathing pattern. Fourteen days after intratracheal instillation of bleomycin, lung compliance, total lung capacity (TLC) and inspiratory capacity were reduced while functional residual capacity and residual volume were increased. Baseline tidal volume (V(T)) was decreased and frequency (fR) increased in the bleomycin treated rats compared with controls. Selective vagal C-fiber blockade did not affect fR or V(T) in any group. Vagotomy resulted in an increase in V(T) and decrease in fR in both groups with the percent increase in V(T)/TLC and decrease in fR being significantly greater in the bleomycin rats compared with controls. Vagotomy also attenuated the significantly elevated P(CO2) in the bleomycin treated rats suggesting that bleomycin-induced alterations in breathing pattern contribute to blood gas abnormalities. We conclude that vagal myelinated afferents contribute to the rapid shallow breathing in bleomycin treated rats.

Original languageEnglish (US)
Pages (from-to)45-61
Number of pages17
JournalRespiration Physiology
Volume108
Issue number1
DOIs
StatePublished - Apr 1997

Fingerprint

Bleomycin
Respiration
Fibrosis
Total Lung Capacity
Lung
Vagotomy
Inspiratory Capacity
Lung Compliance
Functional Residual Capacity
Unmyelinated Nerve Fibers
Residual Volume
Tidal Volume
Wistar Rats
Gases
indium-bleomycin

Keywords

  • Bleomycin
  • Pulmonary fibrosis
  • Rapid shallow breathing
  • Vagal afferents

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Contribution of vagal afferents to breathing pattern in rats with lung fibrosis. / Mansoor, Jim K.; Hyde, Dallas M.; Schelegle, Edward S.

In: Respiration Physiology, Vol. 108, No. 1, 04.1997, p. 45-61.

Research output: Contribution to journalArticle

@article{8b7bbefcfb514bdea008cd2cfaafd72f,
title = "Contribution of vagal afferents to breathing pattern in rats with lung fibrosis",
abstract = "In anesthestized male Wistar rats with bleomycin-induced lung fibrosis we examined the influence of lung vagal non-myelinated and myelinated afferents in setting breathing pattern. Fourteen days after intratracheal instillation of bleomycin, lung compliance, total lung capacity (TLC) and inspiratory capacity were reduced while functional residual capacity and residual volume were increased. Baseline tidal volume (V(T)) was decreased and frequency (fR) increased in the bleomycin treated rats compared with controls. Selective vagal C-fiber blockade did not affect fR or V(T) in any group. Vagotomy resulted in an increase in V(T) and decrease in fR in both groups with the percent increase in V(T)/TLC and decrease in fR being significantly greater in the bleomycin rats compared with controls. Vagotomy also attenuated the significantly elevated P(CO2) in the bleomycin treated rats suggesting that bleomycin-induced alterations in breathing pattern contribute to blood gas abnormalities. We conclude that vagal myelinated afferents contribute to the rapid shallow breathing in bleomycin treated rats.",
keywords = "Bleomycin, Pulmonary fibrosis, Rapid shallow breathing, Vagal afferents",
author = "Mansoor, {Jim K.} and Hyde, {Dallas M.} and Schelegle, {Edward S}",
year = "1997",
month = "4",
doi = "10.1016/S0034-5687(96)02505-4",
language = "English (US)",
volume = "108",
pages = "45--61",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Contribution of vagal afferents to breathing pattern in rats with lung fibrosis

AU - Mansoor, Jim K.

AU - Hyde, Dallas M.

AU - Schelegle, Edward S

PY - 1997/4

Y1 - 1997/4

N2 - In anesthestized male Wistar rats with bleomycin-induced lung fibrosis we examined the influence of lung vagal non-myelinated and myelinated afferents in setting breathing pattern. Fourteen days after intratracheal instillation of bleomycin, lung compliance, total lung capacity (TLC) and inspiratory capacity were reduced while functional residual capacity and residual volume were increased. Baseline tidal volume (V(T)) was decreased and frequency (fR) increased in the bleomycin treated rats compared with controls. Selective vagal C-fiber blockade did not affect fR or V(T) in any group. Vagotomy resulted in an increase in V(T) and decrease in fR in both groups with the percent increase in V(T)/TLC and decrease in fR being significantly greater in the bleomycin rats compared with controls. Vagotomy also attenuated the significantly elevated P(CO2) in the bleomycin treated rats suggesting that bleomycin-induced alterations in breathing pattern contribute to blood gas abnormalities. We conclude that vagal myelinated afferents contribute to the rapid shallow breathing in bleomycin treated rats.

AB - In anesthestized male Wistar rats with bleomycin-induced lung fibrosis we examined the influence of lung vagal non-myelinated and myelinated afferents in setting breathing pattern. Fourteen days after intratracheal instillation of bleomycin, lung compliance, total lung capacity (TLC) and inspiratory capacity were reduced while functional residual capacity and residual volume were increased. Baseline tidal volume (V(T)) was decreased and frequency (fR) increased in the bleomycin treated rats compared with controls. Selective vagal C-fiber blockade did not affect fR or V(T) in any group. Vagotomy resulted in an increase in V(T) and decrease in fR in both groups with the percent increase in V(T)/TLC and decrease in fR being significantly greater in the bleomycin rats compared with controls. Vagotomy also attenuated the significantly elevated P(CO2) in the bleomycin treated rats suggesting that bleomycin-induced alterations in breathing pattern contribute to blood gas abnormalities. We conclude that vagal myelinated afferents contribute to the rapid shallow breathing in bleomycin treated rats.

KW - Bleomycin

KW - Pulmonary fibrosis

KW - Rapid shallow breathing

KW - Vagal afferents

UR - http://www.scopus.com/inward/record.url?scp=0030945722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030945722&partnerID=8YFLogxK

U2 - 10.1016/S0034-5687(96)02505-4

DO - 10.1016/S0034-5687(96)02505-4

M3 - Article

C2 - 9178376

AN - SCOPUS:0030945722

VL - 108

SP - 45

EP - 61

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 1

ER -