Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism

Lauren K. Stewart, Geoffrey W. Peitz, Kristen E. Nordenholz, D. Mark Courtney, Christopher Kabrhel, Alan E. Jones, Matthew T. Rondina, Deborah B. Diercks, James R. Klinger, Jeffrey A. Kline

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Acute pulmonary embolism (PE) can diminish patient quality of life (QoL). The objective was to test whether treatment with tenecteplase has an independent effect on a measurement that reflects QoL in patients with submassive PE. This was a secondary analysis of an 8-center, prospective randomized controlled trial, utilizing multivariate regression to control for predefined predictors of worsened QoL including: age, active malignancy, history of PE or deep venous thrombosis (DVT), recurrent PE or DVT, chronic obstructive pulmonary disease and heart failure. QoL was measured with the physical component summary (PCS) of the SF-36. Analysis included 76 patients (37 randomized to tenecteplase, 39 to placebo). Multivariate regression yielded an equation f(8, 67), P < 0.001, with R<sup>2</sup> = 0.303. Obesity had the largest effect on PCS (β = −8.6, P < 0.001), with tenecteplase second (β = 4.73, P = 0.056). After controlling for all interactions, tenecteplase increased the PCS by +5.37 points (P = 0.027). In patients without any of the defined comorbidities, the coefficient on the tenecteplase variable was not significant (−0.835, P = 0.777). In patients with submassive PE, obesity had the greatest influence on QoL, followed by use of fibrinolysis. Fibrinolysis had a marginal independent effect on patient QoL after controlling for comorbidities, but was not significant in patients without comorbid conditions.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalJournal of Thrombosis and Thrombolysis
Volume40
Issue number2
DOIs
StatePublished - Nov 30 2014
Externally publishedYes

Fingerprint

Fibrinolysis
Pulmonary Embolism
Quality of Life
Venous Thrombosis
Comorbidity
Obesity
Chronic Obstructive Pulmonary Disease
Randomized Controlled Trials
Heart Failure
Placebos
tenecteplase
Neoplasms

Keywords

  • Fibrinolysis
  • Pulmonary embolism
  • Quality of life
  • Submassive

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Stewart, L. K., Peitz, G. W., Nordenholz, K. E., Courtney, D. M., Kabrhel, C., Jones, A. E., ... Kline, J. A. (2014). Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. Journal of Thrombosis and Thrombolysis, 40(2), 161-166. https://doi.org/10.1007/s11239-014-1155-5

Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. / Stewart, Lauren K.; Peitz, Geoffrey W.; Nordenholz, Kristen E.; Courtney, D. Mark; Kabrhel, Christopher; Jones, Alan E.; Rondina, Matthew T.; Diercks, Deborah B.; Klinger, James R.; Kline, Jeffrey A.

In: Journal of Thrombosis and Thrombolysis, Vol. 40, No. 2, 30.11.2014, p. 161-166.

Research output: Contribution to journalArticle

Stewart, LK, Peitz, GW, Nordenholz, KE, Courtney, DM, Kabrhel, C, Jones, AE, Rondina, MT, Diercks, DB, Klinger, JR & Kline, JA 2014, 'Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism', Journal of Thrombosis and Thrombolysis, vol. 40, no. 2, pp. 161-166. https://doi.org/10.1007/s11239-014-1155-5
Stewart, Lauren K. ; Peitz, Geoffrey W. ; Nordenholz, Kristen E. ; Courtney, D. Mark ; Kabrhel, Christopher ; Jones, Alan E. ; Rondina, Matthew T. ; Diercks, Deborah B. ; Klinger, James R. ; Kline, Jeffrey A. / Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. In: Journal of Thrombosis and Thrombolysis. 2014 ; Vol. 40, No. 2. pp. 161-166.
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abstract = "Acute pulmonary embolism (PE) can diminish patient quality of life (QoL). The objective was to test whether treatment with tenecteplase has an independent effect on a measurement that reflects QoL in patients with submassive PE. This was a secondary analysis of an 8-center, prospective randomized controlled trial, utilizing multivariate regression to control for predefined predictors of worsened QoL including: age, active malignancy, history of PE or deep venous thrombosis (DVT), recurrent PE or DVT, chronic obstructive pulmonary disease and heart failure. QoL was measured with the physical component summary (PCS) of the SF-36. Analysis included 76 patients (37 randomized to tenecteplase, 39 to placebo). Multivariate regression yielded an equation f(8, 67), P < 0.001, with R2 = 0.303. Obesity had the largest effect on PCS (β = −8.6, P < 0.001), with tenecteplase second (β = 4.73, P = 0.056). After controlling for all interactions, tenecteplase increased the PCS by +5.37 points (P = 0.027). In patients without any of the defined comorbidities, the coefficient on the tenecteplase variable was not significant (−0.835, P = 0.777). In patients with submassive PE, obesity had the greatest influence on QoL, followed by use of fibrinolysis. Fibrinolysis had a marginal independent effect on patient QoL after controlling for comorbidities, but was not significant in patients without comorbid conditions.",
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