Contrasting Effects of Testosterone and Stanozolol on Serum Lipoprotein Levels

Paul D. Thompson, Eileen M. Cullinane, Stanley P. Sady, Claire Chenevert, Ann L. Saritelli, Mina A. Sady, Peter N. Herbert

Research output: Contribution to journalArticle

193 Scopus citations

Abstract

Oral anabolic steroids produce striking reductions in serum concentrations of high-density lipoprotein (HDL) cholesterol. We hypothesized that this effect related to their route of administration and was unrelated to their androgenic potency. We administered oral stanozolol (6 mg/d) or supraphysiological doses of intramuscular testosterone enanthate (200 mg/wk) to 11 male weight lifters for six weeks in a crossover design. Stanozolol reduced HDL-cholesterol and the HDL2 subfraction by 33% and 71%, respectively. In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction. Apolipoprotein A-I level decreased 40% during stanozolol but only 8% during testosterone treatment. The low-density lipoprotein cholesterol concentration increased 29% with stanozolol and decreased 16% with testosterone treatment. Stanozolol, moreover, increased postheparin hepatic triglyceride lipase activity by 123%, whereas the maximum change during testosterone therapy ( + 25%) was not significant. Weight gain was similar with both drugs, but testosterone was more effective in suppressing gonadotropic hormones. We conclude that the undesirable lipoprotein effects of 17-α-alkylated steroids given orally are different from those of parenteral testosterone and that the latter may be preferable in many clinical situations.

Original languageEnglish (US)
Pages (from-to)1165-1168
Number of pages4
JournalJAMA - Journal of the American Medical Association
Volume261
Issue number8
DOIs
StatePublished - Feb 24 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Thompson, P. D., Cullinane, E. M., Sady, S. P., Chenevert, C., Saritelli, A. L., Sady, M. A., & Herbert, P. N. (1989). Contrasting Effects of Testosterone and Stanozolol on Serum Lipoprotein Levels. JAMA - Journal of the American Medical Association, 261(8), 1165-1168. https://doi.org/10.1001/jama.1989.03420080085036