Contrast medium-induced renal vasoconstriction and endogenous vasoconstrictor hormones

Richard W Katzberg, L. G. Meggs, G. Schulman, N. K. Hollenberg

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Hypertonic solutions, such as contrast media (meglumine/sodium diatrizoate - 76%; Renografin-76), induce vasoconstriction in the renal vascular bed via an unknown mechanism. We assessed a possible role of two vasoconstrictor hormones known to be released by the kidney, angiotensin II (AII) and the prostaglandin, thromboxane. Specific inhibition of AII at the smooth muscle receptor level by saralasin (0.33-0.75 μg/kg/min, IA) did not attenuate the response. Inhibition of prostaglandin formation by indomethacin (4 mg/kg, IV), likewise, did not prevent the decrease in renal perfusion. We conclude that neither AII nor the prostaglandin system mediate the contrast medium-induced renal vasoconstriction.

Original languageEnglish (US)
Pages (from-to)266-268
Number of pages3
JournalBritish Journal of Radiology
Issue number652
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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