Abstract
Hypertonic solutions, such as contrast media (meglumine/sodium diatrizoate - 76%; Renografin-76), induce vasoconstriction in the renal vascular bed via an unknown mechanism. We assessed a possible role of two vasoconstrictor hormones known to be released by the kidney, angiotensin II (AII) and the prostaglandin, thromboxane. Specific inhibition of AII at the smooth muscle receptor level by saralasin (0.33-0.75 μg/kg/min, IA) did not attenuate the response. Inhibition of prostaglandin formation by indomethacin (4 mg/kg, IV), likewise, did not prevent the decrease in renal perfusion. We conclude that neither AII nor the prostaglandin system mediate the contrast medium-induced renal vasoconstriction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 266-268 |
| Number of pages | 3 |
| Journal | British Journal of Radiology |
| Volume | 55 |
| Issue number | 652 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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Contrast medium-induced renal vasoconstriction and endogenous vasoconstrictor hormones. / Katzberg, Richard W; Meggs, L. G.; Schulman, G.; Hollenberg, N. K.
In: British Journal of Radiology, Vol. 55, No. 652, 1982, p. 266-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contrast medium-induced renal vasoconstriction and endogenous vasoconstrictor hormones
AU - Katzberg, Richard W
AU - Meggs, L. G.
AU - Schulman, G.
AU - Hollenberg, N. K.
PY - 1982
Y1 - 1982
N2 - Hypertonic solutions, such as contrast media (meglumine/sodium diatrizoate - 76%; Renografin-76), induce vasoconstriction in the renal vascular bed via an unknown mechanism. We assessed a possible role of two vasoconstrictor hormones known to be released by the kidney, angiotensin II (AII) and the prostaglandin, thromboxane. Specific inhibition of AII at the smooth muscle receptor level by saralasin (0.33-0.75 μg/kg/min, IA) did not attenuate the response. Inhibition of prostaglandin formation by indomethacin (4 mg/kg, IV), likewise, did not prevent the decrease in renal perfusion. We conclude that neither AII nor the prostaglandin system mediate the contrast medium-induced renal vasoconstriction.
AB - Hypertonic solutions, such as contrast media (meglumine/sodium diatrizoate - 76%; Renografin-76), induce vasoconstriction in the renal vascular bed via an unknown mechanism. We assessed a possible role of two vasoconstrictor hormones known to be released by the kidney, angiotensin II (AII) and the prostaglandin, thromboxane. Specific inhibition of AII at the smooth muscle receptor level by saralasin (0.33-0.75 μg/kg/min, IA) did not attenuate the response. Inhibition of prostaglandin formation by indomethacin (4 mg/kg, IV), likewise, did not prevent the decrease in renal perfusion. We conclude that neither AII nor the prostaglandin system mediate the contrast medium-induced renal vasoconstriction.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020032747&partnerID=8YFLogxK
M3 - Article
C2 - 7066636
AN - SCOPUS:0020032747
VL - 55
SP - 266
EP - 268
JO - British Journal of Radiology
JF - British Journal of Radiology
SN - 0007-1285
IS - 652
ER -