Abstract
With a contrast agent, wideband signals have been hypothesized to increase the contrast-to-tissue ratio (CTR). However, nonlinear properties of contrast agents make decoding difficult when applying coded excitation to contrast imaging. Here, we propose two frequency modulated excitation methods to image contrast agents, with a mechanical index (MI) from 0.05 to 0.34. In a single chirp method, one chirp is transmitted, followed by a clutter filter to reject tissue echoes and a matched filter to recover range resolution. In a chirp sequence method, an increasing and decreasing chirp sequence is transmitted followed by subtraction of the compressed echoes to reject tissue echoes (assuming tissue is a linear scatterer at low MI). Ten independent acoustic experiments were performed to evaluate the CTR for chirp and tone burst insonation, with same spatial peak temporal averaged intensity (I SPTA- A significant increase in CTR, ranging from 4 dB to 8 dB, is observed for chirped excitation as compared with tone burst insonation, at an ISPTA of 0.1 and 0.3 mW/cm2 (P < 5×10 -3). Deconvolution of the linear microbubble response from the received echoes is proposed as a method to recover spatial resolution. The difference in the axial resolution between chirp and 3-cycle tone burst insonation is approximately 220 μm. The difference in the mainlobe width between experimental and predicted compressed echoes is less than 20%. The sidelobe amplitude is 9 dB to 16 dB below the mainlobe with a transmitted I SPTA from 0.1 to 6.6 mW/cm2.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| Pages | 220-223 |
| Number of pages | 4 |
| Volume | 1 |
| DOIs | |
| State | Published - 2006 |
| Event | 2006 IEEE International Ultrasonics Symposium, IUS - Vancouver, BC, Canada Duration: Oct 3 2006 → Oct 6 2006 |
Other
| Other | 2006 IEEE International Ultrasonics Symposium, IUS |
|---|---|
| Country | Canada |
| City | Vancouver, BC |
| Period | 10/3/06 → 10/6/06 |
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Keywords
- Chirped excitation
- Contrast-to-tissue ratio
- Deconvolution
- Ultrasound contrast agent imaging
ASJC Scopus subject areas
- Engineering(all)
- Acoustics and Ultrasonics
Cite this
Contrast imaging with chirped excitation. / Sun, Yang; Kruse, Dustin E.; Ferrara, Katherine W.
Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2006. p. 220-223 4151924.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Contrast imaging with chirped excitation
AU - Sun, Yang
AU - Kruse, Dustin E.
AU - Ferrara, Katherine W.
PY - 2006
Y1 - 2006
N2 - With a contrast agent, wideband signals have been hypothesized to increase the contrast-to-tissue ratio (CTR). However, nonlinear properties of contrast agents make decoding difficult when applying coded excitation to contrast imaging. Here, we propose two frequency modulated excitation methods to image contrast agents, with a mechanical index (MI) from 0.05 to 0.34. In a single chirp method, one chirp is transmitted, followed by a clutter filter to reject tissue echoes and a matched filter to recover range resolution. In a chirp sequence method, an increasing and decreasing chirp sequence is transmitted followed by subtraction of the compressed echoes to reject tissue echoes (assuming tissue is a linear scatterer at low MI). Ten independent acoustic experiments were performed to evaluate the CTR for chirp and tone burst insonation, with same spatial peak temporal averaged intensity (I SPTA- A significant increase in CTR, ranging from 4 dB to 8 dB, is observed for chirped excitation as compared with tone burst insonation, at an ISPTA of 0.1 and 0.3 mW/cm2 (P < 5×10 -3). Deconvolution of the linear microbubble response from the received echoes is proposed as a method to recover spatial resolution. The difference in the axial resolution between chirp and 3-cycle tone burst insonation is approximately 220 μm. The difference in the mainlobe width between experimental and predicted compressed echoes is less than 20%. The sidelobe amplitude is 9 dB to 16 dB below the mainlobe with a transmitted I SPTA from 0.1 to 6.6 mW/cm2.
AB - With a contrast agent, wideband signals have been hypothesized to increase the contrast-to-tissue ratio (CTR). However, nonlinear properties of contrast agents make decoding difficult when applying coded excitation to contrast imaging. Here, we propose two frequency modulated excitation methods to image contrast agents, with a mechanical index (MI) from 0.05 to 0.34. In a single chirp method, one chirp is transmitted, followed by a clutter filter to reject tissue echoes and a matched filter to recover range resolution. In a chirp sequence method, an increasing and decreasing chirp sequence is transmitted followed by subtraction of the compressed echoes to reject tissue echoes (assuming tissue is a linear scatterer at low MI). Ten independent acoustic experiments were performed to evaluate the CTR for chirp and tone burst insonation, with same spatial peak temporal averaged intensity (I SPTA- A significant increase in CTR, ranging from 4 dB to 8 dB, is observed for chirped excitation as compared with tone burst insonation, at an ISPTA of 0.1 and 0.3 mW/cm2 (P < 5×10 -3). Deconvolution of the linear microbubble response from the received echoes is proposed as a method to recover spatial resolution. The difference in the axial resolution between chirp and 3-cycle tone burst insonation is approximately 220 μm. The difference in the mainlobe width between experimental and predicted compressed echoes is less than 20%. The sidelobe amplitude is 9 dB to 16 dB below the mainlobe with a transmitted I SPTA from 0.1 to 6.6 mW/cm2.
KW - Chirped excitation
KW - Contrast-to-tissue ratio
KW - Deconvolution
KW - Ultrasound contrast agent imaging
UR - http://www.scopus.com/inward/record.url?scp=47249083471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47249083471&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2006.68
DO - 10.1109/ULTSYM.2006.68
M3 - Conference contribution
AN - SCOPUS:47249083471
SN - 1424402018
SN - 9781424402014
VL - 1
SP - 220
EP - 223
BT - Proceedings - IEEE Ultrasonics Symposium
ER -