Contrast echo studies of cardiac perfusion

Bisphere safety and efficacy

Milind Dhond, Steve Rendig, Ronald Yamamoto, Gregory Pulido, Thomas Ottobani, Glen Tickner, William J Bommer

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate the hemodynamic safety and efficacy of a new air-filled biocompatible echo contrast agent. Method: Blood pressure (BP), heart rate (HR) and transesophageal echoes were monitored in six closed chest dogs; while cardiac output (CO), pulmonary artery (PA), pulmonary artery wedge (PAW) and arterial pressures were continuously monitored in one dog; and myocardial perfusion was imaged in two open chest dogs before, during, and after coronary occlusion with harmonic Acoustic Densitometry (AD) and Power Angio (HP5500) recordings. Serial contrast injections of air-filled biSpheres (Point Biomedical) ranging from 0.5 ml (fluid suspension) to 24 ml (cumulative dose of up to 48 ml) were made in peripheral veins. Results: Left heart enhancement for 60 minutes or longer was easily seen with all 0.5 ml or larger injections. The hemodynamic response was measured as the mean change (Δ) from the pre-injection to post injection values. The hemodynamic changes were: Δ systolic BP 1.47±8.09, Δ diastolic BP 2.06±0.83mmHg, Δ HR 1.06±4.52, and Δ CO 0.22±0.44L/min. (P=NS) Myocardial AD intensity was 35± 5 units in normal myocardium and 10± 5 units in ischemic myocardium (p<.01). Power angio intensity was even brighter in normal and darker in ischemic areas. Conclusions: Air-filled biSphere contrast agents provide reliable and long-lasting left heart opacification and do not alter hemodynamics at individual doses of 0.5-24 ml and cumulative doses of 48 ml. These air-filled biSpheres provide intense myocardial opacification in both harmonic back scatter and Power Angio imaging which easily distinguishes normal from ischemic myocardium. These biologically compatible, long-lasting contrast agents should provide useful physiologic information in health and disease.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume47
Issue number2
StatePublished - Feb 1999

Fingerprint

Hemodynamics
Blood pressure
Perfusion
Contrast Media
Blood Pressure
Safety
Air
Myocardium
Injections
Densitometry
Dogs
Acoustics
Cardiac Output
Acoustic intensity
Thorax
Heart Rate
Pulmonary Wedge Pressure
Coronary Occlusion
Suspensions
Pulmonary Artery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dhond, M., Rendig, S., Yamamoto, R., Pulido, G., Ottobani, T., Tickner, G., & Bommer, W. J. (1999). Contrast echo studies of cardiac perfusion: Bisphere safety and efficacy. Journal of Investigative Medicine, 47(2).

Contrast echo studies of cardiac perfusion : Bisphere safety and efficacy. / Dhond, Milind; Rendig, Steve; Yamamoto, Ronald; Pulido, Gregory; Ottobani, Thomas; Tickner, Glen; Bommer, William J.

In: Journal of Investigative Medicine, Vol. 47, No. 2, 02.1999.

Research output: Contribution to journalArticle

Dhond, M, Rendig, S, Yamamoto, R, Pulido, G, Ottobani, T, Tickner, G & Bommer, WJ 1999, 'Contrast echo studies of cardiac perfusion: Bisphere safety and efficacy', Journal of Investigative Medicine, vol. 47, no. 2.
Dhond M, Rendig S, Yamamoto R, Pulido G, Ottobani T, Tickner G et al. Contrast echo studies of cardiac perfusion: Bisphere safety and efficacy. Journal of Investigative Medicine. 1999 Feb;47(2).
Dhond, Milind ; Rendig, Steve ; Yamamoto, Ronald ; Pulido, Gregory ; Ottobani, Thomas ; Tickner, Glen ; Bommer, William J. / Contrast echo studies of cardiac perfusion : Bisphere safety and efficacy. In: Journal of Investigative Medicine. 1999 ; Vol. 47, No. 2.
@article{af6621a520694720a064b002adfe4fc2,
title = "Contrast echo studies of cardiac perfusion: Bisphere safety and efficacy",
abstract = "The purpose of this study was to evaluate the hemodynamic safety and efficacy of a new air-filled biocompatible echo contrast agent. Method: Blood pressure (BP), heart rate (HR) and transesophageal echoes were monitored in six closed chest dogs; while cardiac output (CO), pulmonary artery (PA), pulmonary artery wedge (PAW) and arterial pressures were continuously monitored in one dog; and myocardial perfusion was imaged in two open chest dogs before, during, and after coronary occlusion with harmonic Acoustic Densitometry (AD) and Power Angio (HP5500) recordings. Serial contrast injections of air-filled biSpheres (Point Biomedical) ranging from 0.5 ml (fluid suspension) to 24 ml (cumulative dose of up to 48 ml) were made in peripheral veins. Results: Left heart enhancement for 60 minutes or longer was easily seen with all 0.5 ml or larger injections. The hemodynamic response was measured as the mean change (Δ) from the pre-injection to post injection values. The hemodynamic changes were: Δ systolic BP 1.47±8.09, Δ diastolic BP 2.06±0.83mmHg, Δ HR 1.06±4.52, and Δ CO 0.22±0.44L/min. (P=NS) Myocardial AD intensity was 35± 5 units in normal myocardium and 10± 5 units in ischemic myocardium (p<.01). Power angio intensity was even brighter in normal and darker in ischemic areas. Conclusions: Air-filled biSphere contrast agents provide reliable and long-lasting left heart opacification and do not alter hemodynamics at individual doses of 0.5-24 ml and cumulative doses of 48 ml. These air-filled biSpheres provide intense myocardial opacification in both harmonic back scatter and Power Angio imaging which easily distinguishes normal from ischemic myocardium. These biologically compatible, long-lasting contrast agents should provide useful physiologic information in health and disease.",
author = "Milind Dhond and Steve Rendig and Ronald Yamamoto and Gregory Pulido and Thomas Ottobani and Glen Tickner and Bommer, {William J}",
year = "1999",
month = "2",
language = "English (US)",
volume = "47",
journal = "Journal of Investigative Medicine",
issn = "1081-5589",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Contrast echo studies of cardiac perfusion

T2 - Bisphere safety and efficacy

AU - Dhond, Milind

AU - Rendig, Steve

AU - Yamamoto, Ronald

AU - Pulido, Gregory

AU - Ottobani, Thomas

AU - Tickner, Glen

AU - Bommer, William J

PY - 1999/2

Y1 - 1999/2

N2 - The purpose of this study was to evaluate the hemodynamic safety and efficacy of a new air-filled biocompatible echo contrast agent. Method: Blood pressure (BP), heart rate (HR) and transesophageal echoes were monitored in six closed chest dogs; while cardiac output (CO), pulmonary artery (PA), pulmonary artery wedge (PAW) and arterial pressures were continuously monitored in one dog; and myocardial perfusion was imaged in two open chest dogs before, during, and after coronary occlusion with harmonic Acoustic Densitometry (AD) and Power Angio (HP5500) recordings. Serial contrast injections of air-filled biSpheres (Point Biomedical) ranging from 0.5 ml (fluid suspension) to 24 ml (cumulative dose of up to 48 ml) were made in peripheral veins. Results: Left heart enhancement for 60 minutes or longer was easily seen with all 0.5 ml or larger injections. The hemodynamic response was measured as the mean change (Δ) from the pre-injection to post injection values. The hemodynamic changes were: Δ systolic BP 1.47±8.09, Δ diastolic BP 2.06±0.83mmHg, Δ HR 1.06±4.52, and Δ CO 0.22±0.44L/min. (P=NS) Myocardial AD intensity was 35± 5 units in normal myocardium and 10± 5 units in ischemic myocardium (p<.01). Power angio intensity was even brighter in normal and darker in ischemic areas. Conclusions: Air-filled biSphere contrast agents provide reliable and long-lasting left heart opacification and do not alter hemodynamics at individual doses of 0.5-24 ml and cumulative doses of 48 ml. These air-filled biSpheres provide intense myocardial opacification in both harmonic back scatter and Power Angio imaging which easily distinguishes normal from ischemic myocardium. These biologically compatible, long-lasting contrast agents should provide useful physiologic information in health and disease.

AB - The purpose of this study was to evaluate the hemodynamic safety and efficacy of a new air-filled biocompatible echo contrast agent. Method: Blood pressure (BP), heart rate (HR) and transesophageal echoes were monitored in six closed chest dogs; while cardiac output (CO), pulmonary artery (PA), pulmonary artery wedge (PAW) and arterial pressures were continuously monitored in one dog; and myocardial perfusion was imaged in two open chest dogs before, during, and after coronary occlusion with harmonic Acoustic Densitometry (AD) and Power Angio (HP5500) recordings. Serial contrast injections of air-filled biSpheres (Point Biomedical) ranging from 0.5 ml (fluid suspension) to 24 ml (cumulative dose of up to 48 ml) were made in peripheral veins. Results: Left heart enhancement for 60 minutes or longer was easily seen with all 0.5 ml or larger injections. The hemodynamic response was measured as the mean change (Δ) from the pre-injection to post injection values. The hemodynamic changes were: Δ systolic BP 1.47±8.09, Δ diastolic BP 2.06±0.83mmHg, Δ HR 1.06±4.52, and Δ CO 0.22±0.44L/min. (P=NS) Myocardial AD intensity was 35± 5 units in normal myocardium and 10± 5 units in ischemic myocardium (p<.01). Power angio intensity was even brighter in normal and darker in ischemic areas. Conclusions: Air-filled biSphere contrast agents provide reliable and long-lasting left heart opacification and do not alter hemodynamics at individual doses of 0.5-24 ml and cumulative doses of 48 ml. These air-filled biSpheres provide intense myocardial opacification in both harmonic back scatter and Power Angio imaging which easily distinguishes normal from ischemic myocardium. These biologically compatible, long-lasting contrast agents should provide useful physiologic information in health and disease.

UR - http://www.scopus.com/inward/record.url?scp=33750096749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750096749&partnerID=8YFLogxK

M3 - Article

VL - 47

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

SN - 1081-5589

IS - 2

ER -