Contrast detection in infants with fragile X syndrome

F. Farzin, D. Whitney, Randi J Hagerman, S. M. Rivera

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Studies have reported that a selective deficit in visual motion processing is present in certain developmental disorders, including Williams syndrome and autism. More recent evidence suggests a visual motion impairment is also present in adults with fragile X syndrome (FXS), the most common form of inherited mental retardation. The goal of the current study was to examine low-level cortical visual processing in infants diagnosed with FXS in order to explore the developmental origin of this putative deficit. We measured contrast detection of first-order (luminance-defined) and second-order (contrast-defined) gratings at two levels of temporal frequency, 0 Hz (static) and 4 Hz (moving). Results indicate that infants with FXS display significantly higher detection thresholds only for the second-order, moving stimuli compared to mental age-matched typically developing controls.

Original languageEnglish (US)
Pages (from-to)1471-1478
Number of pages8
JournalVision Research
Issue number13
StatePublished - Jun 2008


  • Contrast detection
  • Forced-choice preferential looking
  • Fragile X syndrome
  • Motion
  • Second-order
  • Threshold

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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