Contrast-assisted ultrasound for sentinel lymph node detection in spontaneously arising canine head and neck tumors

David M. Lurie, Bernard Seguin, Philip D Schneider, Frank J Verstraete, Erik R Wisner

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


OBJECTIVES: We sought to evaluate a minimally invasive contrast-assisted ultrasound (US) technique for sentinel lymph node (SLN) localization. METHODS: Microbubble contrast medium was injected into peritumoral tissues in 10 dogs with spontaneous head or neck tumors. Regional lymph nodes (LNs) were imaged up to 20 minutes after contrast administration using power Doppler US. Comparative lymphoscintigraphy studies were performed in all dogs by peritumoral injection of 99mTc-sulfur colloid administered around the primary lesion. RESULTS: US contrast enhancement of SLN revealed sentinel nodes and associated lymphatics in 8 of 10 dogs. In each instance in which contrast-enhanced LN was identified with US, a corresponding SLN was detected by lymphoscintigraphy. Multiple SLNs were present in 2 dogs. Regional lymph nodes were positive for metastasis in 1 dog and reactive in 9 dogs. CONCLUSIONS: Contrast-assisted US is effective in localizing SLN. This technique could reduce or eliminate many of the limitations of current SLN detection procedures.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalInvestigative Radiology
Issue number4
StatePublished - Apr 2006


  • Cancer staging
  • Contrast-assisted ultrasound
  • Sentinel lymph node
  • Ultrasound contrast media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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