Contraction rate of rat cardiac cells in culture: Responses to prolonged perfusion

Michael A. Savageau, John P. Steward

Research output: Contribution to journalArticlepeer-review


Rat cardiac muscle cells In culture were subjected to perfusion under constant conditions for periods of 8-16 hours. Capillary tubes were used as perfusion chambers to avoid the disadvantages for kinetic studies inherent in most other perfusion chambers. The contraction rates of these cells displayed a temporal response to perfusion which correlated with the age of the cells in culture. After prolonged perfusion with fresh medium, a peaked response in the contraction rate was observed when the perfusion medium was abruptly changed to medium that had been used to support the growth of a dense culture of cardiac cells for 5 days (conditioned medium).

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
Issue number3
StatePublished - Aug 1967
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery
  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics


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