@inproceedings{65526128d5d84acda86ab07c878db343,

title = "Continuous time dynamic PET imaging using list mode data",

abstract = "We describe a method for computing a continuous time estimate of dynamic changes in tracer density using list mode PET data. The tracer density in each voxel is modeled as an inhomogeneous Poisson process whose rate function can be represented using a cubic B-spline basis. An estimate of these rate functions is obtained by maximizing the likelihood of the arrival times of each detected photon pair over the control vertices of the spline. By resorting the list mode data into a standard sinogram plus a “timogram” that retains the arrival times of each of the events, we are able to perform efficient computation that exploits the symmetry inherent in the ordered sinogram. The maximum likelihood estimator uses quadratic temporal and spatial smoothness penalties and an additional penalty term to enforce non-negativity. Corrections for scatter and randoms are described and the results of studies using simulated and human data are included.",

author = "Nichols, {Thomas E.} and Jinyi Qi and Leahy, {Richard M.}",

year = "1999",

language = "English (US)",

isbn = "3540661670",

volume = "1613",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "98--111",

booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

note = "16th International conference on Information Processing in Medical Imaging, IPMI 1999 ; Conference date: 28-06-1999 Through 02-07-1999",

}