Continuous magnetophoretic enrichment of rare tumor cells

D. Nawarathna; Pappanaicken R Kumaresan; Y. Zhang; B. Ferguson; S. H. Oh; K. S. Lam; H. T. Soh

Continuous magnetophoretic enrichment of rare tumor cells

D. Nawarathna, Pappanaicken R Kumaresan, Y. Zhang, B. Ferguson, S. H. Oh, K. S. Lam, H. T. Soh

Biochemistry and Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present the Continuous-flow Magnetic Activated Cell Sorter (CMACS) device which is capable of enriching rare magnetic particles with high purity. The microfabricated ferromagnetic strips within the microfluidic channels create high magnetic field gradients, which generate the magnetophoretic separation forces. We report on the effective separation of magnetically labeled Human Lymphoma (Jurkat) cells from non-target cells and compare its performance against commercially available macro-scale systems.

Original language	English (US)
Title of host publication	Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Editors	Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
Publisher	Chemical and Biological Microsystems Society
Pages	122-124
Number of pages	3
ISBN (Electronic)	9780979806407
State	Published - 2007
Event	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France Duration: Oct 7 2007 → Oct 11 2007

Publication series

Name	Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country	France
City	Paris
Period	10/7/07 → 10/11/07

Keywords

Magnetic separation
Rare cell sorting

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

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Nawarathna, D., Kumaresan, P. R., Zhang, Y., Ferguson, B., Oh, S. H., Lam, K. S., & Soh, H. T. (2007). Continuous magnetophoretic enrichment of rare tumor cells. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 122-124). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.

Continuous magnetophoretic enrichment of rare tumor cells. / Nawarathna, D.; Kumaresan, Pappanaicken R; Zhang, Y.; Ferguson, B.; Oh, S. H.; Lam, K. S.; Soh, H. T.

Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. ed. / Jean-Louis Viovy; Patrick Tabeling; Stephanie Descroix; Laurent Malaquin. Chemical and Biological Microsystems Society, 2007. p. 122-124 (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nawarathna, D, Kumaresan, PR, Zhang, Y, Ferguson, B, Oh, SH, Lam, KS & Soh, HT 2007, Continuous magnetophoretic enrichment of rare tumor cells. in J-L Viovy, P Tabeling, S Descroix & L Malaquin (eds), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, Chemical and Biological Microsystems Society, pp. 122-124, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, Paris, France, 10/7/07.

Nawarathna D, Kumaresan PR, Zhang Y, Ferguson B, Oh SH, Lam KS et al. Continuous magnetophoretic enrichment of rare tumor cells. In Viovy J-L, Tabeling P, Descroix S, Malaquin L, editors, Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. Chemical and Biological Microsystems Society. 2007. p. 122-124. (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

Nawarathna, D. ; Kumaresan, Pappanaicken R ; Zhang, Y. ; Ferguson, B. ; Oh, S. H. ; Lam, K. S. ; Soh, H. T. / Continuous magnetophoretic enrichment of rare tumor cells. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. editor / Jean-Louis Viovy ; Patrick Tabeling ; Stephanie Descroix ; Laurent Malaquin. Chemical and Biological Microsystems Society, 2007. pp. 122-124 (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

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