Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs

Praveen Kumar Chandrasekharan, Munmun Rawat, Jayasree Nair, Sylvia F. Gugino, Carmon Koenigsknecht, Daniel D. Swartz, Payam Vali, Bobby Mathew, Satyanarayana Lakshminrusimha

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The Neonatal Resuscitation Program (NRP) recommends close monitoring of oxygenation during the resuscitation of newborns using a pulse oximeter. However, there are no guidelines for monitoring carbon dioxide (CO2) to assess ventilation. Considering that cerebral blood flow (CBF) correlates directly with PaCO2, continuous capnography monitoring of end-tidal CO2 (ETCO2) may limit fluctuations in PaCO2 and, therefore, CBF during resuscitation of asphyxiated infants. Objective: To evaluate whether continuous monitoring of ETCO2 with capnography during resuscitation of asphyxiated term lambs with meconium aspiration will prevent fluctuations in PaCO2 and carotid arterial blood flow (CABF). Methods: Fifty-four asphyxiated term lambs with meconium aspiration syndrome were mechanically ventilated from birth to 60 min of age. Ventilatory parameters were adjusted based on clinical observation (chest excursion) and frequent arterial blood gas analysis in 24 lambs (control group) and 30 lambs (capnography group) received additional continuous ETCO2 monitoring. Left CABF was monitored. We aimed to maintain PaCO2 between 35 and 50 mm Hg and ETCO2 between 30 and 45 mm Hg. Results: There was a significant correlation between ETCO2 and PaCO2 (R = 0.7, p < 0.001), between PaCO2 and carotid flow (R = 0.52, p < 0.001) and between ETCO2 and carotid flow (R = 0.5, p < 0.001). PaCO2 and CABF during the first 60 min of age showed significantly higher fluctuation in the control group compared to the capnography group. Conclusion: Continuous monitoring of ETCO2 using capnography with mechanical ventilation during and after resuscitation in asphyxiated term lambs with meconium aspiration limits fluctuations in PaCO2 and CABF and may potentially limit brain injury.

Original languageEnglish (US)
Pages (from-to)265-273
Number of pages9
JournalNeonatology
Volume109
Issue number4
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Capnography
Carbon Dioxide
Resuscitation
Meconium Aspiration Syndrome
Cerebrovascular Circulation
Control Groups
Blood Gas Analysis
Artificial Respiration
Brain Injuries
Ventilation
Thorax
Observation
Parturition
Newborn Infant
Guidelines

Keywords

  • Capnography
  • Carbon dioxide
  • Carotid blood flow

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

Chandrasekharan, P. K., Rawat, M., Nair, J., Gugino, S. F., Koenigsknecht, C., Swartz, D. D., ... Lakshminrusimha, S. (2016). Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs. Neonatology, 109(4), 265-273. https://doi.org/10.1159/000443303

Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs. / Chandrasekharan, Praveen Kumar; Rawat, Munmun; Nair, Jayasree; Gugino, Sylvia F.; Koenigsknecht, Carmon; Swartz, Daniel D.; Vali, Payam; Mathew, Bobby; Lakshminrusimha, Satyanarayana.

In: Neonatology, Vol. 109, No. 4, 01.06.2016, p. 265-273.

Research output: Contribution to journalArticle

Chandrasekharan, PK, Rawat, M, Nair, J, Gugino, SF, Koenigsknecht, C, Swartz, DD, Vali, P, Mathew, B & Lakshminrusimha, S 2016, 'Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs', Neonatology, vol. 109, no. 4, pp. 265-273. https://doi.org/10.1159/000443303
Chandrasekharan PK, Rawat M, Nair J, Gugino SF, Koenigsknecht C, Swartz DD et al. Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs. Neonatology. 2016 Jun 1;109(4):265-273. https://doi.org/10.1159/000443303
Chandrasekharan, Praveen Kumar ; Rawat, Munmun ; Nair, Jayasree ; Gugino, Sylvia F. ; Koenigsknecht, Carmon ; Swartz, Daniel D. ; Vali, Payam ; Mathew, Bobby ; Lakshminrusimha, Satyanarayana. / Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs. In: Neonatology. 2016 ; Vol. 109, No. 4. pp. 265-273.
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AU - Koenigsknecht, Carmon

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