Contemporary management of muscle-invasive bladder cancer

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The current standard treatment for muscle-invasive nonmetastatic bladder cancer is neoadjuvant platinum-based chemotherapy followed by radical cystectomy. However, neoadjuvant chemotherapy is not widely accepted even with level 1 evidence. Adjuvant chemotherapy should be discussed if patients have not received neoadjuvant chemotherapy before surgery and have high-risk pathologic features. Although not considered standard of care, bladder-sparing therapy can be considered for highly selected patients and for those medically unfit for surgery. Even though there are no level 1 data, the treatment outcomes for highly select patients given bladder-sparing therapy appear promising, with many patients retaining a functional bladder. Personalized chemotherapy is currently being actively pursued to target the underlying molecular changes and tailor to individual needs.

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalExpert Review of Anticancer Therapy
Volume12
Issue number7
DOIs
StatePublished - Jul 2012

Keywords

  • bladder urothelial carcinoma
  • chemotherapy
  • cisplatin
  • personalized chemotherapy
  • targeted therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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