Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

Chad L. Cox, Kimber Stanhope, Jean Marc Schwarz, James L. Graham, Bonnie Hatcher, Steven C. Griffen, Andrew A. Bremer, Lars Berglund, John P McGahan, Nancy L. Keim, Peter J Havel

Research output: Contribution to journalArticle

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Abstract

Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women. Methods. As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35kg/m2) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured. Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P<0.0001) and RBP-4 concentrations (P=0.012), as well as plasma GGT activity (P=0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P=0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P=0.024). Conclusions: These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.

Original languageEnglish (US)
Article number68
JournalNutrition and Metabolism
Volume9
DOIs
StatePublished - 2012

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Retinol-Binding Proteins
Beverages
Transferases
Fructose
Uric Acid
Glucose
Liver
Fasting
Enzymes
Biomarkers
Prospective Studies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. / Cox, Chad L.; Stanhope, Kimber; Schwarz, Jean Marc; Graham, James L.; Hatcher, Bonnie; Griffen, Steven C.; Bremer, Andrew A.; Berglund, Lars; McGahan, John P; Keim, Nancy L.; Havel, Peter J.

In: Nutrition and Metabolism, Vol. 9, 68, 2012.

Research output: Contribution to journalArticle

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title = "Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans",
abstract = "Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women. Methods. As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35kg/m2) consumed glucose- or fructose-sweetened beverages providing 25{\%} of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured. Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P<0.0001) and RBP-4 concentrations (P=0.012), as well as plasma GGT activity (P=0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P=0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P=0.024). Conclusions: These findings suggest that consumption of fructose at 25{\%} of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.",
author = "Cox, {Chad L.} and Kimber Stanhope and Schwarz, {Jean Marc} and Graham, {James L.} and Bonnie Hatcher and Griffen, {Steven C.} and Bremer, {Andrew A.} and Lars Berglund and McGahan, {John P} and Keim, {Nancy L.} and Havel, {Peter J}",
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doi = "10.1186/1743-7075-9-68",
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T1 - Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

AU - Cox, Chad L.

AU - Stanhope, Kimber

AU - Schwarz, Jean Marc

AU - Graham, James L.

AU - Hatcher, Bonnie

AU - Griffen, Steven C.

AU - Bremer, Andrew A.

AU - Berglund, Lars

AU - McGahan, John P

AU - Keim, Nancy L.

AU - Havel, Peter J

PY - 2012

Y1 - 2012

N2 - Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women. Methods. As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35kg/m2) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured. Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P<0.0001) and RBP-4 concentrations (P=0.012), as well as plasma GGT activity (P=0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P=0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P=0.024). Conclusions: These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.

AB - Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women. Methods. As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35kg/m2) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured. Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P<0.0001) and RBP-4 concentrations (P=0.012), as well as plasma GGT activity (P=0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P=0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P=0.024). Conclusions: These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.

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