Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Jay V Solnick; C. Josenhans; S. Suerbaum; L. S. Tompkins; A. Labigne

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Jay V Solnick, C. Josenhans, S. Suerbaum, L. S. Tompkins, A. Labigne

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

Original language	English (US)
Pages (from-to)	3718-3721
Number of pages	4
Journal	Infection and Immunity
Volume	63
Issue number	9
State	Published - 1995

ASJC Scopus subject areas

Immunology

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title = "Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae",

abstract = "Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.",

author = "Solnick, {Jay V} and C. Josenhans and S. Suerbaum and Tompkins, {L. S.} and A. Labigne",

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AU - Tompkins, L. S.

AU - Labigne, A.

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AB - Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

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