Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Jay V Solnick, C. Josenhans, S. Suerbaum, L. S. Tompkins, A. Labigne

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Abstract

Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

Original languageEnglish (US)
Pages (from-to)3718-3721
Number of pages4
JournalInfection and Immunity
Volume63
Issue number9
StatePublished - 1995

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ASJC Scopus subject areas

  • Immunology

Cite this

Solnick, J. V., Josenhans, C., Suerbaum, S., Tompkins, L. S., & Labigne, A. (1995). Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae. Infection and Immunity, 63(9), 3718-3721.