Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Jay V Solnick; C. Josenhans; S. Suerbaum; L. S. Tompkins; A. Labigne

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Jay V Solnick, C. Josenhans, S. Suerbaum, L. S. Tompkins, A. Labigne

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

Original language	English (US)
Pages (from-to)	3718-3721
Number of pages	4
Journal	Infection and Immunity
Volume	63
Issue number	9
State	Published - 1995

ASJC Scopus subject areas

Immunology

Cite this

@article{27cbeeffb6c848f4bf26417740207be2,

title = "Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae",

abstract = "Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.",

author = "Solnick, {Jay V} and C. Josenhans and S. Suerbaum and Tompkins, {L. S.} and A. Labigne",

year = "1995",

language = "English (US)",

volume = "63",

pages = "3718--3721",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

AU - Solnick, Jay V

AU - Josenhans, C.

AU - Suerbaum, S.

AU - Tompkins, L. S.

AU - Labigne, A.

PY - 1995

Y1 - 1995

N2 - Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

AB - Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

UR - http://www.scopus.com/inward/record.url?scp=0029090124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029090124&partnerID=8YFLogxK

M3 - Article

C2 - 7642313

AN - SCOPUS:0029090124

VL - 63

SP - 3718

EP - 3721

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 9

ER -

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this