TY - JOUR
T1 - CONSORT extension for reporting N-of-1 trials (CENT) 2015
T2 - Explanation and elaboration
AU - Shamseer, Larissa
AU - Sampson, Margaret
AU - Bukutu, Cecilia
AU - Schmid, Christopher H.
AU - Nikles, Jane
AU - Tate, Robyn
AU - Johnston, Bradley C.
AU - Zucker, Deborah
AU - Shadish, William R.
AU - Kravitz, Richard L
AU - Guyatt, Gordon
AU - Altman, Douglas G.
AU - Moher, David
AU - Vohra, Sunita
PY - 2015
Y1 - 2015
N2 - N-of-1 trials are a useful tool for clinicians who want to determine the effectiveness of a treatment in a particular individual. The reporting of N-of-1 trials has been variable and incomplete, hindering their usefulness in clinical decision making and by future researchers. This document presents the CONSORT (Consolidated Standards of Reporting Trials) extension for N-of-1 trials (CENT 2015). CENT 2015 extends the CONSORT 2010 guidance to facilitate the preparation and appraisal of reports of an individual N-of-1 trial or a series of prospectively planned, multiple, crossover N-of-1 trials. CENT 2015 elaborates on 14 items of the CONSORT 2010 checklist, totalling 25 checklist items (44 sub-items), and recommends diagrams to help authors document the progress of one participant through a trial or more than one participant through a trial or series of trials, as applicable. Examples of good reporting and evidence based rationale for CENT 2015 checklist items are provided.
AB - N-of-1 trials are a useful tool for clinicians who want to determine the effectiveness of a treatment in a particular individual. The reporting of N-of-1 trials has been variable and incomplete, hindering their usefulness in clinical decision making and by future researchers. This document presents the CONSORT (Consolidated Standards of Reporting Trials) extension for N-of-1 trials (CENT 2015). CENT 2015 extends the CONSORT 2010 guidance to facilitate the preparation and appraisal of reports of an individual N-of-1 trial or a series of prospectively planned, multiple, crossover N-of-1 trials. CENT 2015 elaborates on 14 items of the CONSORT 2010 checklist, totalling 25 checklist items (44 sub-items), and recommends diagrams to help authors document the progress of one participant through a trial or more than one participant through a trial or series of trials, as applicable. Examples of good reporting and evidence based rationale for CENT 2015 checklist items are provided.
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U2 - 10.1016/j.jclinepi.2015.05.018
DO - 10.1016/j.jclinepi.2015.05.018
M3 - Article
C2 - 26272791
AN - SCOPUS:84939824335
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
ER -