Consideration of connective tissue dysfunction in the fragile X syndrome

Randi J Hagerman, K. Van Housen, A. C M Smith, L. McGavran

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Eleven cytogenetically documented patients with the fragile X syndrome were evaluated for hyperextensibility of the finger joints and the presence of other manifestations of connective tissue dysfunction. All of the patients had hyperextensibility of several finger joints and many had features such as flat feet, highly arched palate and the ability to voluntarily dislocate finger joints. These traits, particularly hyperextensibility of the joints, are a useful aid in the clinical diagnosis of the fragile X syndrome.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalAmerican Journal of Medical Genetics
Volume17
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Finger Joint
Fragile X Syndrome
Connective Tissue
Flatfoot
Palate
Joints

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Consideration of connective tissue dysfunction in the fragile X syndrome. / Hagerman, Randi J; Van Housen, K.; Smith, A. C M; McGavran, L.

In: American Journal of Medical Genetics, Vol. 17, No. 1, 1984, p. 111-121.

Research output: Contribution to journalArticle

Hagerman, RJ, Van Housen, K, Smith, ACM & McGavran, L 1984, 'Consideration of connective tissue dysfunction in the fragile X syndrome', American Journal of Medical Genetics, vol. 17, no. 1, pp. 111-121.
Hagerman, Randi J ; Van Housen, K. ; Smith, A. C M ; McGavran, L. / Consideration of connective tissue dysfunction in the fragile X syndrome. In: American Journal of Medical Genetics. 1984 ; Vol. 17, No. 1. pp. 111-121.
@article{6b0203fa8b2e4c0e8d0d7939d94d3fb9,
title = "Consideration of connective tissue dysfunction in the fragile X syndrome",
abstract = "Eleven cytogenetically documented patients with the fragile X syndrome were evaluated for hyperextensibility of the finger joints and the presence of other manifestations of connective tissue dysfunction. All of the patients had hyperextensibility of several finger joints and many had features such as flat feet, highly arched palate and the ability to voluntarily dislocate finger joints. These traits, particularly hyperextensibility of the joints, are a useful aid in the clinical diagnosis of the fragile X syndrome.",
author = "Hagerman, {Randi J} and {Van Housen}, K. and Smith, {A. C M} and L. McGavran",
year = "1984",
language = "English (US)",
volume = "17",
pages = "111--121",
journal = "American Journal of Medical Genetics",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Consideration of connective tissue dysfunction in the fragile X syndrome

AU - Hagerman, Randi J

AU - Van Housen, K.

AU - Smith, A. C M

AU - McGavran, L.

PY - 1984

Y1 - 1984

N2 - Eleven cytogenetically documented patients with the fragile X syndrome were evaluated for hyperextensibility of the finger joints and the presence of other manifestations of connective tissue dysfunction. All of the patients had hyperextensibility of several finger joints and many had features such as flat feet, highly arched palate and the ability to voluntarily dislocate finger joints. These traits, particularly hyperextensibility of the joints, are a useful aid in the clinical diagnosis of the fragile X syndrome.

AB - Eleven cytogenetically documented patients with the fragile X syndrome were evaluated for hyperextensibility of the finger joints and the presence of other manifestations of connective tissue dysfunction. All of the patients had hyperextensibility of several finger joints and many had features such as flat feet, highly arched palate and the ability to voluntarily dislocate finger joints. These traits, particularly hyperextensibility of the joints, are a useful aid in the clinical diagnosis of the fragile X syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0021331978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021331978&partnerID=8YFLogxK

M3 - Article

C2 - 6711590

AN - SCOPUS:0021331978

VL - 17

SP - 111

EP - 121

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 1552-4825

IS - 1

ER -