Congenital self-healing reticulohistiocytosis: Concern for a poor prognosis

Larissa N Larsen, Melissa Reyes Merin, Thomas Konia, April Wang Armstrong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Congenital self-healing reticulohistiocytosis (CSHRH) is a rare type of Langerhans cell histiocytosis with potential for relapse and systemic involvement. Whereas CSHRH was traditionally considered a benign disease, there is an approximately 3 percent risk of mortality and a 10 percent chance of relapse. This article, using an extensive review of cases since Hashimoto and Pritzker first described the condition in 1973, highlights the various presentations of CSHRH and reveals high rates of relapse and systemic involvement in cases that specifically address features of CSHRH occurring within the first year of life. The findings from this review will highlight the importance of considering LCH in the differential diagnosis when evaluating a neonate with congenital skin eruptions. Timely diagnosis of CSHRH and treatment of systemic involvement may decrease the likelihood of adverse outcomes. These patients may require closer follow-up and monitoring than previously recommended, especially in the first year of life when relapses and systemic involvement occur most frequently.

Original languageEnglish (US)
Pages (from-to)2
Number of pages1
JournalDermatology Online Journal
Volume18
Issue number10
StatePublished - Oct 2012

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Recurrence
Langerhans Cell Histiocytosis
Differential Diagnosis
Newborn Infant
Skin
Mortality
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Congenital self-healing reticulohistiocytosis : Concern for a poor prognosis. / Larsen, Larissa N; Merin, Melissa Reyes; Konia, Thomas; Armstrong, April Wang.

In: Dermatology Online Journal, Vol. 18, No. 10, 10.2012, p. 2.

Research output: Contribution to journalArticle

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