Congenital myopathy with abundant nemaline rods in a cat

Stephanie A. Kube, Karen Vernau, Richard A Lecouteur, Andrew P. Mizisin, G. Diane Shelton

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Nemaline myopathy is associated with rod-shaped structures in muscle fibers. At least seven distinct clinical forms have been described in humans and mutations have been identified in five different thin-filament genes. Only a few cases of spontaneously occurring nemaline myopathy have been reported in animals and include an adult-onset form in a family of cats and an early-onset form in a dog. Here, we describe a 2-year-old male, neutered, domestic shorthaired cat that was referred to the Veterinary Medical Teaching Hospital, University of California-Davis, for evaluation of chronic, progressive weakness, and fine tremors. Neurologic deficits were restricted to the neuromuscular system. Electromyography showed mild to moderate diffuse spontaneous activity. Although rod bodies were prominent on light and electron microscopic evaluation of biopsies from several muscles, sarcoplasmic accumulations of dystrophin, desmin, and spectrin also were identified by immunohistochemistry. These findings may represent the occurrence of rod bodies in conjunction with a protein-aggregate myopathy.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalNeuromuscular Disorders
Volume16
Issue number3
DOIs
StatePublished - Mar 2006

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Keywords

  • Animal model
  • Generalized weakness
  • Muscle
  • Protein aggregate myopathy
  • Tremors

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

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