Abstract
Congenital melanocytic nevi (CMN) are present at birth or arise during the first few weeks of life. They are quite common, may have a heritable component, and can present with marked differences in size, shape, color, and location. Histologic and dermatoscopic findings may help suggest the diagnosis, but they are not entirely specific. CMN are categorized based on size, and larger lesions can have a significant psychosocial impact and other complications. They are associated with a variety of dermatologic lesions, ranging from benign to malignant. The risk of malignant transformation varies, with larger CMN carrying a significantly higher risk of malignant melanoma (MM), although with an absolute risk that is lower than is commonly believed. They may also be associated with neuromelanosis, which may be of greater concern than cutaneous MM. The information presented herein aims to help dermatologists determine when it is prudent to obtain a biopsy specimen or excise these lesions, to obtain radiographic imaging, and to involve other specialists (eg, psychiatrists and neurologists) in the patient's care.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American Academy of Dermatology |
| Volume | 67 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2012 |
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Keywords
- congenital nevus
- imaging
- malignant melanoma
- neurocutaneous melanosis
- neuromelanosis
- tethered spinal cord
ASJC Scopus subject areas
- Dermatology
Cite this
Congenital melanocytic nevi : Where are we now?: Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. / Alikhan, Ali; Ibrahimi, Omar A.; Eisen, Daniel B.
In: Journal of the American Academy of Dermatology, Vol. 67, No. 4, 10.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Congenital melanocytic nevi
T2 - Where are we now?: Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis
AU - Alikhan, Ali
AU - Ibrahimi, Omar A.
AU - Eisen, Daniel B
PY - 2012/10
Y1 - 2012/10
N2 - Congenital melanocytic nevi (CMN) are present at birth or arise during the first few weeks of life. They are quite common, may have a heritable component, and can present with marked differences in size, shape, color, and location. Histologic and dermatoscopic findings may help suggest the diagnosis, but they are not entirely specific. CMN are categorized based on size, and larger lesions can have a significant psychosocial impact and other complications. They are associated with a variety of dermatologic lesions, ranging from benign to malignant. The risk of malignant transformation varies, with larger CMN carrying a significantly higher risk of malignant melanoma (MM), although with an absolute risk that is lower than is commonly believed. They may also be associated with neuromelanosis, which may be of greater concern than cutaneous MM. The information presented herein aims to help dermatologists determine when it is prudent to obtain a biopsy specimen or excise these lesions, to obtain radiographic imaging, and to involve other specialists (eg, psychiatrists and neurologists) in the patient's care.
AB - Congenital melanocytic nevi (CMN) are present at birth or arise during the first few weeks of life. They are quite common, may have a heritable component, and can present with marked differences in size, shape, color, and location. Histologic and dermatoscopic findings may help suggest the diagnosis, but they are not entirely specific. CMN are categorized based on size, and larger lesions can have a significant psychosocial impact and other complications. They are associated with a variety of dermatologic lesions, ranging from benign to malignant. The risk of malignant transformation varies, with larger CMN carrying a significantly higher risk of malignant melanoma (MM), although with an absolute risk that is lower than is commonly believed. They may also be associated with neuromelanosis, which may be of greater concern than cutaneous MM. The information presented herein aims to help dermatologists determine when it is prudent to obtain a biopsy specimen or excise these lesions, to obtain radiographic imaging, and to involve other specialists (eg, psychiatrists and neurologists) in the patient's care.
KW - congenital nevus
KW - imaging
KW - malignant melanoma
KW - neurocutaneous melanosis
KW - neuromelanosis
KW - tethered spinal cord
UR - http://www.scopus.com/inward/record.url?scp=84866432665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866432665&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2012.06.023
DO - 10.1016/j.jaad.2012.06.023
M3 - Article
VL - 67
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 4
ER -