Congenital hypothyroid dwarfism in a family of giant schnauzers.

D. S. Greco, Edward C Feldman, M. E. Peterson, J. L. Turner, C. M. Hodges, L. W. Shipman

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Congenital hypothyroid dwarfism was diagnosed in a family of Giant Schnauzers. Three female and two male puppies from different litters were evaluated for dwarfism, lethargy, somnolence, gait abnormalities, and constipation. On physical examination, disproportionate dwarfism (n = 5), macroglossia (n = 3), hypothermia (n = 3), delayed dental eruption (n = 3), ataxia (n = 2), and abdominal distension (n = 1) were identified. Results of initial laboratory tests showed anemia (n = 4), hypercholesterolemia (n = 4), hypercalcemia (n = 2), and transudative abdominal effusion (n = 1). Radiographic skeletal surveys disclosed epiphyseal dysgenesis and delayed skeletal maturation (n = 5). A diagnosis of hypothyroidism was established on the basis of low basal serum thyroxine concentrations that failed to increase following the administration of TSH (n = 5) and markedly reduced to absent thyroid image when evaluated with gamma camera imaging of the thyroid gland (n = 4). In the two dogs that were most thoroughly evaluated, the results of thyroid histology, prolonged TSH testing, and repeat thyroid imaging, after three daily injections of TSH, were all consistent with secondary or tertiary, rather than primary, hypothyroidism. When TSH was administered over a period of 3 consecutive days (5 IU/day, subcutaneously), serum thyroid hormone response became normal and resulted in a normal thyroid image in the two dogs re-evaluated with gamma camera imaging. Daily treatment with oral levothyroxine (20 micrograms/kg) resulted in complete remission in puppies (n = 4) treated prior to 4 months of age. The other puppy failed to attain normal breed standards for height.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume5
Issue number2
StatePublished - Mar 1991
Externally publishedYes

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Dwarfism
dwarfing
puppies
Thyroid Gland
hypothyroidism
image analysis
cameras
hypercalcemia
constipation
Hypothyroidism
Thyroxine
L-thyroxine
dogs
thyroid gland
hypothermia
Radionuclide Imaging
hypercholesterolemia
remission
gait
thyroid hormones

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Congenital hypothyroid dwarfism in a family of giant schnauzers. / Greco, D. S.; Feldman, Edward C; Peterson, M. E.; Turner, J. L.; Hodges, C. M.; Shipman, L. W.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 5, No. 2, 03.1991, p. 57-65.

Research output: Contribution to journalArticle

Greco, D. S. ; Feldman, Edward C ; Peterson, M. E. ; Turner, J. L. ; Hodges, C. M. ; Shipman, L. W. / Congenital hypothyroid dwarfism in a family of giant schnauzers. In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 1991 ; Vol. 5, No. 2. pp. 57-65.
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