Congenital cardiac outflow tract abnormalities in dogs: Prevalence and pattern of inheritance from 2008 to 2017

Eric S. Ontiveros, Samantha L. Fousse, Amanda E. Crofton, Timothy Hodge, Catherine Gunther-Harrington, Lance C Visser, Joshua A Stern

Research output: Contribution to journalArticle

Abstract

Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3% of overall hospital admissions and 4.7% for all dogs seen by the cardiology service. The prevalence for PS was 0.41% of overall hospital admissions and 6.1% of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59 and 4.46%, respectively) and odds ratio (52.43 and 34.73, respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8 and 2.7%, respectively) and odds ratio (13.32 and 7.52, respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.

Original languageEnglish (US)
Article number00052
JournalFrontiers in Veterinary Science
Volume6
Issue numberFEB
DOIs
StatePublished - Jan 1 2019

Fingerprint

Subvalvular Aortic Stenosis
Inheritance Patterns
Pulmonary Valve Stenosis
inheritance (genetics)
Dogs
lungs
dogs
heart diseases
Heart Diseases
Pedigree
Cardiology
Teaching Hospitals
pedigree
odds ratio
Newfoundland (dog breed)
Odds Ratio
Newfoundland and Labrador
Animal Hospitals
Rottweiler
Golden Retriever

Keywords

  • Congenital heart disease
  • Genetics
  • Inheritance
  • Prevalence
  • Pulmonic stenosis
  • Subvalvular aortic stenosis
  • Veterinary

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Congenital cardiac outflow tract abnormalities in dogs : Prevalence and pattern of inheritance from 2008 to 2017. / Ontiveros, Eric S.; Fousse, Samantha L.; Crofton, Amanda E.; Hodge, Timothy; Gunther-Harrington, Catherine; Visser, Lance C; Stern, Joshua A.

In: Frontiers in Veterinary Science, Vol. 6, No. FEB, 00052, 01.01.2019.

Research output: Contribution to journalArticle

@article{8b2abb676ddf45fc87bc394f24dd8824,
title = "Congenital cardiac outflow tract abnormalities in dogs: Prevalence and pattern of inheritance from 2008 to 2017",
abstract = "Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3{\%} of overall hospital admissions and 4.7{\%} for all dogs seen by the cardiology service. The prevalence for PS was 0.41{\%} of overall hospital admissions and 6.1{\%} of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59 and 4.46{\%}, respectively) and odds ratio (52.43 and 34.73, respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8 and 2.7{\%}, respectively) and odds ratio (13.32 and 7.52, respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.",
keywords = "Congenital heart disease, Genetics, Inheritance, Prevalence, Pulmonic stenosis, Subvalvular aortic stenosis, Veterinary",
author = "Ontiveros, {Eric S.} and Fousse, {Samantha L.} and Crofton, {Amanda E.} and Timothy Hodge and Catherine Gunther-Harrington and Visser, {Lance C} and Stern, {Joshua A}",
year = "2019",
month = "1",
day = "1",
doi = "10.3389/fvets.2019.00052",
language = "English (US)",
volume = "6",
journal = "Frontiers in Veterinary Science",
issn = "2297-1769",
publisher = "Frontiers Media S. A.",
number = "FEB",

}

TY - JOUR

T1 - Congenital cardiac outflow tract abnormalities in dogs

T2 - Prevalence and pattern of inheritance from 2008 to 2017

AU - Ontiveros, Eric S.

AU - Fousse, Samantha L.

AU - Crofton, Amanda E.

AU - Hodge, Timothy

AU - Gunther-Harrington, Catherine

AU - Visser, Lance C

AU - Stern, Joshua A

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3% of overall hospital admissions and 4.7% for all dogs seen by the cardiology service. The prevalence for PS was 0.41% of overall hospital admissions and 6.1% of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59 and 4.46%, respectively) and odds ratio (52.43 and 34.73, respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8 and 2.7%, respectively) and odds ratio (13.32 and 7.52, respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.

AB - Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3% of overall hospital admissions and 4.7% for all dogs seen by the cardiology service. The prevalence for PS was 0.41% of overall hospital admissions and 6.1% of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59 and 4.46%, respectively) and odds ratio (52.43 and 34.73, respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8 and 2.7%, respectively) and odds ratio (13.32 and 7.52, respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.

KW - Congenital heart disease

KW - Genetics

KW - Inheritance

KW - Prevalence

KW - Pulmonic stenosis

KW - Subvalvular aortic stenosis

KW - Veterinary

UR - http://www.scopus.com/inward/record.url?scp=85064452690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064452690&partnerID=8YFLogxK

U2 - 10.3389/fvets.2019.00052

DO - 10.3389/fvets.2019.00052

M3 - Article

AN - SCOPUS:85064452690

VL - 6

JO - Frontiers in Veterinary Science

JF - Frontiers in Veterinary Science

SN - 2297-1769

IS - FEB

M1 - 00052

ER -