Conflict-related anterior cingulate functional connectivity is associated with past suicidal ideation and behavior in recent-onset psychotic major mood disorders

Michael J. Minzenberg, Tyler A. Lesh, Tara A Niendam, Yaoan Cheng, Cameron S Carter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume28
Issue number4
DOIs
StatePublished - 2016

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Psychotic Affective Disorders
Suicidal Ideation
Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Corpus Striatum
Occipital Lobe
Parietal Lobe
Major Depressive Disorder
Motor Cortex
Bipolar Disorder
Psychotic Disorders
Magnetic Resonance Imaging
Brain
Conflict (Psychology)

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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abstract = "Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.",
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AU - Minzenberg, Michael J.

AU - Lesh, Tyler A.

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AU - Cheng, Yaoan

AU - Carter, Cameron S

PY - 2016

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