Conflict-related anterior cingulate functional connectivity is associated with past suicidal ideation and behavior in recent-onset psychotic major mood disorders

Michael Mizenberg, Tyler A. Lesh, Tara A. Niendam, Yaoan Cheng, Cameron S. Carter

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume28
Issue number4
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Psychiatry and Mental health

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