Abstract
Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent. (ii) Static-mode, where the channel is filled with a stationary gel, mimics the case of drug-eluting brain implant. We demonstrate the utility of the platform with a fluorescein-loaded nanoporous gold coating and monitor in real-time the release kinetics both under deionized water infusion and an agarose gel-filled channel via fluorescence microscopy coupled to a LabVIEW-based interface.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3331-3337 |
| Number of pages | 7 |
| Journal | Lab on a Chip |
| Volume | 17 |
| Issue number | 19 |
| DOIs | |
| State | Published - Jan 1 2017 |
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ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
Cite this
Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings. / Li, Zidong; Seker, Erkin.
In: Lab on a Chip, Vol. 17, No. 19, 01.01.2017, p. 3331-3337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings
AU - Li, Zidong
AU - Seker, Erkin
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent. (ii) Static-mode, where the channel is filled with a stationary gel, mimics the case of drug-eluting brain implant. We demonstrate the utility of the platform with a fluorescein-loaded nanoporous gold coating and monitor in real-time the release kinetics both under deionized water infusion and an agarose gel-filled channel via fluorescence microscopy coupled to a LabVIEW-based interface.
AB - Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent. (ii) Static-mode, where the channel is filled with a stationary gel, mimics the case of drug-eluting brain implant. We demonstrate the utility of the platform with a fluorescein-loaded nanoporous gold coating and monitor in real-time the release kinetics both under deionized water infusion and an agarose gel-filled channel via fluorescence microscopy coupled to a LabVIEW-based interface.
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UR - http://www.scopus.com/inward/citedby.url?scp=85030102855&partnerID=8YFLogxK
U2 - 10.1039/c7lc00851a
DO - 10.1039/c7lc00851a
M3 - Article
C2 - 28868535
AN - SCOPUS:85030102855
VL - 17
SP - 3331
EP - 3337
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 19
ER -