Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings

Zidong Li, Erkin Seker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent. (ii) Static-mode, where the channel is filled with a stationary gel, mimics the case of drug-eluting brain implant. We demonstrate the utility of the platform with a fluorescein-loaded nanoporous gold coating and monitor in real-time the release kinetics both under deionized water infusion and an agarose gel-filled channel via fluorescence microscopy coupled to a LabVIEW-based interface.

Original languageEnglish (US)
Pages (from-to)3331-3337
Number of pages7
JournalLab on a Chip
Volume17
Issue number19
DOIs
StatePublished - Jan 1 2017

Fingerprint

Microfluidics
Gels
Equipment and Supplies
Coatings
Drug-Eluting Stents
Fluorescein
Fluorescence Microscopy
Gold
Pharmaceutical Preparations
Sepharose
Atherosclerosis
Gold coatings
Kinetics
Stents
Water
Deionized water
Fluorescence microscopy
Brain
Therapeutics
Microchannels

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings. / Li, Zidong; Seker, Erkin.

In: Lab on a Chip, Vol. 17, No. 19, 01.01.2017, p. 3331-3337.

Research output: Contribution to journalArticle

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