Conference report on contractures in musculoskeletal and neurological conditions

Glen H. Nuckolls, Kathi Kinnett, Sudarshan Dayanidhi, Andrea A. Domenighetti, Tina Duong, Yetrib Hathout, Michael W. Lawlor, Sabrina S.M. Lee, S. Peter Magnusson, Craig M. McDonald, Elizabeth M. McNally, Natalie F. Miller, Bradley B. Olwin, Preeti Raghavan, Thomas J. Roberts, Seward B. Rutkove, John F. Sarwark, Claudia R. Senesac, Leslie F. Vogel, Glenn A. WalterRebecca J. Willcocks, William Z. Rymer, Richard L. Lieber

Research output: Contribution to journalArticle

Abstract

Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19–20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • cerebral palsy
  • contracture
  • Duchenne muscular dystrophy
  • muscle
  • stroke

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Conference report on contractures in musculoskeletal and neurological conditions'. Together they form a unique fingerprint.

  • Cite this

    Nuckolls, G. H., Kinnett, K., Dayanidhi, S., Domenighetti, A. A., Duong, T., Hathout, Y., Lawlor, M. W., Lee, S. S. M., Magnusson, S. P., McDonald, C. M., McNally, E. M., Miller, N. F., Olwin, B. B., Raghavan, P., Roberts, T. J., Rutkove, S. B., Sarwark, J. F., Senesac, C. R., Vogel, L. F., ... Lieber, R. L. (Accepted/In press). Conference report on contractures in musculoskeletal and neurological conditions. Muscle and Nerve. https://doi.org/10.1002/mus.26845