Conduction aphasia, sensory-motor integration, and phonological short-term memory - An aggregate analysis of lesion and fMRI data

Bradley R. Buchsbaum, Juliana Baldo, Kayoko Okada, Karen F. Berman, Nina Dronkers, Mark D'Esposito, Gregory Hickok

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Conduction aphasia is a language disorder characterized by frequent speech errors, impaired verbatim repetition, a deficit in phonological short-term memory, and naming difficulties in the presence of otherwise fluent and grammatical speech output. While traditional models of conduction aphasia have typically implicated white matter pathways, recent advances in lesions reconstruction methodology applied to groups of patients have implicated left temporoparietal zones. Parallel work using functional magnetic resonance imaging (fMRI) has pinpointed a region in the posterior most portion of the left planum temporale, area Spt, which is critical for phonological working memory. Here we show that the region of maximal lesion overlap in a sample of 14 patients with conduction aphasia perfectly circumscribes area Spt, as defined in an aggregate fMRI analysis of 105 subjects performing a phonological working memory task. We provide a review of the evidence supporting the idea that Spt is an interface site for the integration of sensory and vocal tract-related motor representations of complex sound sequences, such as speech and music and show how the symptoms of conduction aphasia can be explained by damage to this system.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalBrain and Language
Volume119
Issue number3
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Conduction Aphasia
sensory motor
speech disorder
Short-Term Memory
Magnetic Resonance Imaging
Language Disorders
Temazepam
Music
deficit
damages
reconstruction
music
Phonological Short-term Memory
Functional Magnetic Resonance Imaging
Lesion
methodology
language
evidence
Group

Keywords

  • Brain lesion
  • Conduction aphasia
  • Phonological short-term memory
  • Planum temporale
  • Sensorimotor integration
  • Speech production
  • Working memory

ASJC Scopus subject areas

  • Linguistics and Language
  • Speech and Hearing
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Language and Linguistics

Cite this

Conduction aphasia, sensory-motor integration, and phonological short-term memory - An aggregate analysis of lesion and fMRI data. / Buchsbaum, Bradley R.; Baldo, Juliana; Okada, Kayoko; Berman, Karen F.; Dronkers, Nina; D'Esposito, Mark; Hickok, Gregory.

In: Brain and Language, Vol. 119, No. 3, 12.2011, p. 119-128.

Research output: Contribution to journalArticle

Buchsbaum, Bradley R. ; Baldo, Juliana ; Okada, Kayoko ; Berman, Karen F. ; Dronkers, Nina ; D'Esposito, Mark ; Hickok, Gregory. / Conduction aphasia, sensory-motor integration, and phonological short-term memory - An aggregate analysis of lesion and fMRI data. In: Brain and Language. 2011 ; Vol. 119, No. 3. pp. 119-128.
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